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Roles of PPARs in health and disease

Abstract

In developed societies, chronic diseases such as diabetes, obesity, atherosclerosis and cancer are responsible for most deaths. These ailments have complex causes involving genetic, environmental and nutritional factors. There is evidence that a group of closely related nuclear receptors, called peroxisome proliferator-activated receptors (PPARs), may be involved in these diseases. This, together with the fact that PPAR activity can be modulated by drugs such as thiazolidinediones and fibrates, has instigated a huge research effort into PPARs1. Here we present the latest developments in the PPAR field, with particular emphasis on the physiological function of PPARs during various nutritional states, and the possible role of PPARs in several chronic diseases.

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Figure 1: PPARs at the basic level.
Figure 2: Action of PPARα and PPARγ at the cellular level.
Figure 3: Overview of the roles of PPARα and PPARγ during feeding and fasting.

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Acknowledgements

S.K. was supported by fellowships from the European Molecular Biology Organization and the Roche Research Foundation. Work in the author's laboratory is financed by the Swiss National Science Foundation, the Etat de Vaud, and Human Frontier Science Programme.

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Correspondence to Walter Wahli.

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Kersten, S., Desvergne, B. & Wahli, W. Roles of PPARs in health and disease. Nature 405, 421–424 (2000). https://doi.org/10.1038/35013000

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