Abstract
Cloning and sequencing of the complementary DNA for platelet-derived endothelial cell growth factor indicates that it is a novel factor distinct from previously characterized proteins. The factor, a protein with a relative molecular mass of about 45,000, stimulates endothelial cell growth and chemotaxis in vitro and angiogenesis in vivo.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Miyazono, K., Okabe, T., Urabe, A., Takaku, F. & Heldin, C.-H. J. biol. Chem. 262, 4,098–4,103 (1987).
Miyazono, K. & Heldin, C.-H. Biochemistry 28, 1,704–1,710 (1989).
Lobb, R. R., Harper, J. W. & Fett, J. W. Analyt. Biochem. 154, 1–14 (1986).
Gospodarowicz, D., Neufeld, G. & Schweigerer, L. Molec. cell. Endocr. 46, 187–204 (1986).
Kozak, M. Nucleic Acids Res. 12, 857–872 (1984).
Fiddes, J. C. & Goodman, H. M. Nature 286, 684–687 (1980).
Alien, G. in Sequencing of Proteins and Peptides (eds Work, T. S. & Burdon, R. H.) (Elsevier, Amsterdam, 1981).
Piwnica-Worms, H. et al. Molec cell. Biol. 6, 2,033–2,040 (1986).
Jaye, M. et al. Science 233, 541–545 (1986).
Abraham, J. A. et al. EMBO J. 5, 2,523–2,528 (1986).
Fasano, O., Birnhaum, D., Edlung, L., L., Fogh, J. & Wigler, M. Molec. cell. Biol. 4, 1,695–1,705 (1984).
Folkman, J. & Klagsbrun, M. Science 235, 442–447 (1987).
Schreiber, A. B., Winkler, M. E. & Derynck, R. Science 232, 1,250–1,253 (1986).
Roberts, A. B. et al. Proc. natn. Acad. Sci. U.S.A. 84, 4,167–4,171 (1986).
Wiseman, D. M., Polverini, P. J., Kamp, D. W. & Leibovich, S. J. Biochem. biophys. Res. Commun. 157, 793–800 (1988).
Frater-Schröder, M., Risau, W., Hallmann, R., Gautschi, P. & Böhlen, P. Proc. natn. Acad. Sci. U.S.A. 84, 5,277–5,281 (1987).
Leibovich, S. J. et al. Nature 329, 630–632 (1987).
Fett, J. W. et al. Biochemistry 24, 5,480–5,486 (1985).
Ross, R. New Engl. J. Med. 314, 488–500 (1986).
Ross, R., Raines, E. E. & Bowen-Pope, D. F. Cell 46, 155–159 (1986).
Han, J. H., Stratowa, C. & Rutter, W. J. Biochemistry 26, 1,617–1,625 (1987).
Watson, C. J. & Jackson, J. F. in DNA Cloning Vol. 1 (ed. Glover, D. M.) 79–88 (IRL, Oxford, 1985).
Lathe, R. J. molec. Biol. 183, 1–12 (1985).
Ullrich, A., Berman, C. H., Dull, T. J., Gray, A. & Lee, J. M. EMBO J. 3, 361–364 (1984).
Yanisch-Perron, C., Veira, J. & Messing, J. Gene 33, 103–119 (1985).
Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5,463–5,467 (1977).
Maxam, W. W. & Gilbert, W. Meth. Enzym. 65, 499–560 (1980).
Blobel, G. & Dobberstein, B. J. cell. Biol. 67, 835–851 (1975).
Terracio, L. et al. J. cell. Biol. 107, 1,947–1,957 (1988).
Zerwes, H.-G. & Risau, W. J. cell. Biol. 105, 2,037–2,041 (1987).
Risau, W. Proc. natn. Acad. Sci. U.S.A. 83, 3,855–3,859 (1986).
Crum, R., Szabo, S. & Folkman, J. Science 230, 1,375–1,377 (1985).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ishikawa, F., Miyazono, K., Hellman, U. et al. Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature 338, 557–562 (1989). https://doi.org/10.1038/338557a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/338557a0
This article is cited by
-
Angiogenic content of microparticles in patients with diabetes and coronary artery disease predicts networks of endothelial dysfunction
Cardiovascular Diabetology (2022)
-
Loss of thymidine phosphorylase activity disrupts adipocyte differentiation and induces insulin-resistant lipoatrophic diabetes
BMC Medicine (2022)
-
Endothelial plasticity drives aberrant vascularization and impedes cardiac repair after myocardial infarction
Nature Cardiovascular Research (2022)
-
Prognostic significance of the combination of preoperative red cell distribution width and platelet distribution width in patients with gastric cancer
BMC Cancer (2021)
-
Prognostic significance of platelet × C-reactive protein multiplier in patients with esophageal squamous cell carcinoma
Surgery Today (2020)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.