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A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice

Nature volume 336, pages 446–450 (1988)Cite this article

Abstract

Transgenic mice carrying an immunoglobulin enhancer-driven c-myc oncogene develop rapid-onset pre-B cell lymphomas. The incidence of these malignancies is greatly reduced when an additional transgene encoding the membrane-bound form (but not the secreted form) of human Ig/ji is bred into the susceptible strain. This suppressive effect correlates with a subtle alteration in B-cell development induced by the immunoglobulin transgene.

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Authors and Affiliations

  1. Department of Genetics, Howard Hughes Medical Institute and Harvard Medical School, Boston, Massachusetts, 02115, USA

    Michel C. Nussenzweig, Emmett V. Schmidt, Albert C. Shaw, Eric Sinn, Juanita Campos-Torres & Philip Leder

  2. Pediatric/Oncology Department, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Bernard Mathey-Prevot

  3. Department of Pathology, Childrens Hospital of Los Angeles, Los Angeles, California, 90027, USA

    Paul K. Pattengale

Authors
  1. Michel C. Nussenzweig
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  2. Emmett V. Schmidt
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  3. Albert C. Shaw
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  4. Eric Sinn
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  5. Juanita Campos-Torres
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  6. Bernard Mathey-Prevot
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  7. Paul K. Pattengale
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  8. Philip Leder
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Nussenzweig, M., Schmidt, E., Shaw, A. et al. A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice. Nature 336, 446–450 (1988). https://doi.org/10.1038/336446a0

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