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Regulation of calcium influx by second messengers in rat mast cells

Nature volume 334, pages 499–504 (1988)Cite this article

Abstract

Biphasic increases in the free intracellular calcium concentration, consisting of a large initial transient followed by a sustained elevation, are frequently observed in non-excitable cells following stimulation. In rat peritoneal mast cells a cAMP- and Ca-activated chloride current can interact with IP3-dependent calcium influx to provide the sustained elevation of intracellular Ca concentration following transient IP3-induced release of calcium from intracellular stores. This novel combination of second messenger systems provides a flexible means to modulate calcium-dependent processes such as exocytosis.

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Authors and Affiliations

  1. Max-Planck-Institut für Biophysikalische Chemie, D-3400, Göttingen, FRG

    Reinhold Penner, Gary Matthews & Erwin Neher

  2. Department of Neurobiology, SUNY, Stony Brook, New York, 11794, USA

    Gary Matthews

Authors
  1. Reinhold Penner
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  2. Gary Matthews
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  3. Erwin Neher
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Penner, R., Matthews, G. & Neher, E. Regulation of calcium influx by second messengers in rat mast cells. Nature 334, 499–504 (1988). https://doi.org/10.1038/334499a0

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