Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

Article metrics

Abstract

In mice the product of the Mlsa locus is an unusual antigen capable of interaction with certain products of the major histocompatibility locus (MHC) to form a ligand for a large portion of the T-cell α/β receptor repertoire, including nearly all receptors that use Vβ8.1. The presence of Mlsa/ MHC during T-cell development results in the deletion of T cells that express Vβ8.1 documenting the importance of clonal deletion in establishing tolerance to self antigens.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Babbitt, B., Allen, P., Matsueda, G., Haber, E. & Unanue, E. Nature 317, 359–361 (1985).

  2. 2

    Buus, S., Sette, A., Colon, S., Jenis, D. & Grey, H. Cell 47, 1071–1077 (1986).

  3. 3

    Zinkernagel, R. & Doherty, P. Nature 251, 547–548 (1974).

  4. 4

    Bevan, M. et al. Immun. Reviews 42, 1–270 (1978).

  5. 5

    Bjorkman, P. et al. Nature 329, 506–512 (1987).

  6. 6

    Bjorkman, P. et al. Nature 329, 512–518 (1987).

  7. 7

    Born, W. et al. J. Immun. 138, 999–1008 (1987).

  8. 8

    McDuffie, M., Born, W., Marrack, P. & Kappler, J. Proc. natn. Acad. Sci. U.S.A 83, 8728–8733 (1986).

  9. 9

    Kruisbeek, A. et al. J. exp. Med. 161, 1029–1047 (1985).

  10. 10

    Bevan, M. Nature 269, 417–419 (1977).

  11. 11

    Zinkernagel, R. et al. J. exp. Med. 147, 882–896 (1978).

  12. 12

    Billingham, R., Brent, L. & Medawar, P. Nature 172, 603–606 (1956).

  13. 13

    Festenstein, H. Transplant. Rev. 15, 62–88 (1973).

  14. 14

    Festenstein, H. Transplantation 18, 555–557 (1974).

  15. 15

    Festenstein, H., Bishop, C. & Taylor, B. Immunogenetics 5, 357–361 (1977).

  16. 16

    Janeway, C., Lerner, E., Jason, J. & B. Jones Immunogenetics 10, 481–497 (1980).

  17. 17

    Jones, B. & Janeway, C. Immunogenetics 16, 243–256 (1982).

  18. 18

    Lynch, D., Gress, R., Needleman, B., Rosenberg, S. & Hodes, R. J. Immun. 134, 2071–2078 (1985).

  19. 19

    Webb, S., Molnar-Kimber, K., Jennifer, B., Sprent, J. & Wilson, D. J. exp. Med. 154, 1970–1974 (1981).

  20. 20

    Webb, S. et al. J. exp. Med. 161, 269–274 (1985).

  21. 21

    Staerz, U., Rammensee, H., Benedetto, J. & Bevan, M. J. Immun. 134, 3994–4000 (1985).

  22. 22

    Behlke, M. et al. J. exp. Med. 165, 257–262 (1987).

  23. 23

    Haskins, K. et al. J. exp. Med. 160, 452–471 (1984).

  24. 24

    Staerz, U. & Bevan, M. in Molecular Biology of the Immune System (eds Streilein, J., Ahmad, F., Black, S., Blomberg, B. & Voellmy, R.) 61–64 (Cambridge University Press, Cambridge, 1985).

  25. 25

    Kappler, J. et al. Cell 49, 263–271 (1987).

  26. 26

    Kappler, J., Roehm, N. & Marrack, P. Cell 49, 273–280 (1987).

  27. 27

    Roehm, N. et al. J. Immun. 135, 2176–2182 (1985).

  28. 28

    Abe, R., Ryan, J. & R. Hodes, J. exp. Med. 165, 1113–1129 (1987).

  29. 29

    Click, R. et al. J. Immun. 139, 321–325 (1987).

  30. 30

    Taylor, B. in Genetic Variants and Strains of the Laboratory Mouse (ed. Green, M.) 397 (Fisher, Stuttgart, 1981).

  31. 31

    Roehm, N. et al. Cell 38, 577–584 (1984).

  32. 32

    Glasebrook, A. & Fitch, F. J. exp. Med. 151, 876–895 (1980).

  33. 33

    Katz, M. & Janeway, C. J. Immun. 134, 2064–2070 (1985).

  34. 34

    Hasek, M. et al. Immun. Rev. 46, 1–86, 123–146 (1979).

  35. 35

    Allen, P., McKean, D., Beck, B., Sheffield, J. & Glimcher, L. J. exp. Med. 162, 1264–1274 (1985).

  36. 36

    Ogasawara, K., Maloy, W. & Schwartz, R. Nature 325, 450–452 (1987).

  37. 37

    Fink, P., Matis, L., McElligott, D., Bookman, M. & Hedrick, S. Nature 321, 219–226 (1986).

  38. 38

    Winoto, A. et al. Nature 324, 679–682 (1986).

  39. 39

    Kappler, J., Skidmore, B., White, J. & Marrack, P. J. exp. Med. 153, 1198–1214 (1981).

  40. 40

    Marrack, P. in Isolation, Characterization and Utilization of T-Lymphocyte Clones (eds Fathman, G. & Fitch, F.) 508–510 (Academic, New York, 1982).

  41. 41

    Kranz, D., Sherman, D., Sitkovsky, M., Pasternack, M. & Eisen, H. Proc. natn. Acad. Sci. U.S.A. 81, 573–577 (1984).

  42. 42

    Kaye, J., Porcelli, S., Tite, J., Jones, B. & Janeway, C. J. exp. Med. 158, 836–856 (1983).

  43. 43

    White, J., Haskins, K., Marrack, P. & Kappler, J. (1983) J. Immun. 130, 1033–1037 (1983).

  44. 44

    Blackman, M. et al. Cell 47, 349–357 (1986).

  45. 45

    Endres, R., Marrack, P. & Kappler, J. (1983). J. Immun. 131, 1656–1662 (1983).

  46. 46

    Choi, H. et al. Proc. natn. Acad. Sci. U.S.A. 84, 1992–1996 (1987).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.