Abstract
In mice the product of the Mlsa locus is an unusual antigen capable of interaction with certain products of the major histocompatibility locus (MHC) to form a ligand for a large portion of the T-cell α/β receptor repertoire, including nearly all receptors that use Vβ8.1. The presence of Mlsa/ MHC during T-cell development results in the deletion of T cells that express Vβ8.1 documenting the importance of clonal deletion in establishing tolerance to self antigens.
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Kappler, J., Staerz, U., White, J. et al. Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex. Nature 332, 35–40 (1988). https://doi.org/10.1038/332035a0
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DOI: https://doi.org/10.1038/332035a0
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