Letter | Published:

A novel type of human papillomavirus associated with genital neoplasias

Nature volume 321, pages 246249 (15 May 1986) | Download Citation

Subjects

Abstract

The role of human papillomaviruses (HPVs) in the development of genital neoplasias has been well documented1–5. The genomes of two HPV types, HPV16 and HPV18, have been found to be associated with about 70% of invasive carcinomas of the uterine cervix2,4,6. As, under non-stringent hybridization conditions, HPV DNA sequences have been detected in about 90% of cervical carcinomas4,6, it seems likely that additional HPV types are associated with these tumours. Here we report the molecular cloning and characterization of a novel HPV type, tentatively named HPV33, whose sequences have been detected in 4–8% of biopsies of genital intra-epithelial neoplasias and cervical invasive carcinomas, usually as free monomeric or oligomeric molecules. However, in one specimen of vulvar Bowen's disease, HPV33 DNA sequences were integrated in the host-cell genome. Thus, HPV33 probably represents an additional type of potentially oncogenic genital HPV.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    , & Int. J. Gynec. Path. 1, 75–94 (1982).

  2. 2.

    , , & Proc. natn. Acad. Sci. U.S.A. 80, 3812–3815 (1983).

  3. 3.

    , , , & Int. J. Cancer 32, 563–565 (1983).

  4. 4.

    et al. EMBO J. 3, 1151–1157 (1984).

  5. 5.

    , , & J. Virol. 54, 675–681 (1985).

  6. 6.

    , , & UCLA Symp. molec. cell. Biol., New Ser. 32, 47–56 (1985).

  7. 7.

    , , & J. Virol. 36, 395–407 (1980).

  8. 8.

    & Gene 10, 249–259 (1980).

  9. 9.

    , & Molecular Cloning. A Laboratory Manual (Cold Spring Harbor Laboratory, New York, 1982).

  10. 10.

    , , & J. Virol. 48, 340–351 (1983).

  11. 11.

    , , & J. Virol. 21, 1210–1214 (1977).

  12. 12.

    , & J. Virol. 40, 932–935 (1981).

  13. 13.

    , , & J. Virol. 44, 393–400 (1982).

  14. 14.

    , , & J. Virol. 43, 436–447 (1982).

  15. 15.

    , , , & J. Virol. 47, 363–366 (1983).

  16. 16.

    , & J. Virol. 52, 1019–1023 (1984).

  17. 17.

    et al. J. Virol. 52, 1013–1018 (1984).

  18. 18.

    , , & J. invest. Derm. 82, 362–366 (1984).

  19. 19.

    , , & J. gen Virol. 66, 1515–1522 (1985).

  20. 20.

    et al. J. Virol. 57, 688–692 (1986).

  21. 21.

    , & Int. J. Cancer 37, 61–65 (1986).

  22. 22.

    et al. J. invest. Derm. (in the press).

  23. 23.

    et al. J. invest. Derm. 76, 97–102 (1981).

  24. 24.

    , & Meth. Enzym. 21D, 413–428 (1971).

  25. 25.

    , & C.r. Acad. Sci., Paris 294, 581–586 (1982).

  26. 26.

    , , , & Virology 145, 181–185 (1985).

  27. 27.

    , & Proc. natn. Acad. Sci. U.S.A. 82, 5540–5544 (1985).

  28. 28.

    et al. Nature 314, 111–114 (1985).

  29. 29.

    & Proc. natn. Acad. Sci. U.S.A. 79, 790–794 (1982).

  30. 30.

    CIBA Fdn Symp. 120, 157–169 (1986).

  31. 31.

    et al. Cold Spring Harb. Conf. Cell Prolif. 7, 259–282 (1980).

  32. 32.

    , , , & Molec. gen. Genet. 170, 161–169 (1979).

  33. 33.

    & Science 196, 180–182 (1977).

  34. 34.

    et al. Nucleic Acids Res. 12, 7035–7056 (1984).

Download references

Author information

Affiliations

  1. Unité des Papillomavirus, INSERM U190, Institut Pasteur, 75015 Paris, France

    • Sylvie Beaudenon
    • , Dina Kremsdorf
    • , Odile Croissant
    •  & Gérard Orth
  2. Unité de Recombinaison et Expression Génétique, INSERM U163, Institut Pasteur, 75015 Paris, France

    • Simon Wain-Hobson
  3. Department of Dermatology, Warsaw School of Medicine, Warsaw, Poland

    • Stefania Jablonska

Authors

  1. Search for Sylvie Beaudenon in:

  2. Search for Dina Kremsdorf in:

  3. Search for Odile Croissant in:

  4. Search for Stefania Jablonska in:

  5. Search for Simon Wain-Hobson in:

  6. Search for Gérard Orth in:

About this article

Publication history

Received

Accepted

Published

DOI

https://doi.org/10.1038/321246a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.