Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

Nature volume 318, pages 533–538 (1985)Cite this article

Abstract

Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin μ or κ enhancer frequently develop a fatal lymphoma within a few months of birth. Since the tumours represent both immature and mature B lymphocytes, constitutive c-myc expression appears to be highly leukaemogenic at several stages of B-cell maturation. These myc mice should aid study of lymphoma development, B-cell ontogeny and immunoglobulin regulation.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Get just this article for as long as you need it

$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

References

  1. Bishop, J. M. A. Rev. Biochem. 52, 301–354 (1983).

    Article  CAS  Google Scholar 

  2. Varmus, H. E. A. Rev. Genet. 18, 553–612 (1984).

    Article  CAS  Google Scholar 

  3. Duesberg, P. H. Science 228, 669–677 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Palmiter, R. D. & Brinster, R. L. Cell 41, 343–345 (1985).

    Article  CAS  PubMed  Google Scholar 

  5. Brinster, R. L. et al. Nature 306, 332–336 (1983).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  6. Storb, U. et al. Nature 310, 238–241 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Grosschedl, R., Weaver, D., Baltimore, D. & Costantini, F. Cell 38, 647–658 (1984).

    Article  CAS  PubMed  Google Scholar 

  8. Rusconi, S. & Köhler, G. Nature 314, 330–334 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  9. Brinster, R. L. et al. Cell 37, 367–379 (1984).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Palmiter, R. D., Chen, H. Y., Messing, A. & Brinster, R. L. Nature 316, 457–460 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  11. Hanahan, D. Nature 315, 115–122 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. Messing, A., Chen, H. Y., Palmiter, R. D. & Brinster, R. L. Nature 316, 461–463.

  13. Stewart, T., Pattengale, P. & Leder, P. Cell 38, 627–637 (1984).

    Article  CAS  PubMed  Google Scholar 

  14. Hayward, W., Neel, B. G. & Astrin, S. Nature 290, 475–480 (1981).

    Article  ADS  CAS  PubMed  Google Scholar 

  15. Payne, G. S., Bishop, J. M., & Varmus, H. E. Nature 295, 209–214 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  16. Corcoran, L. M., Adams, J. M., Dunn, A. R. & Cory, S. Cell 37, 113–122 (1984).

    Article  CAS  PubMed  Google Scholar 

  17. Sefton, G., Cuypers, H., Zijlstra, M., Melief, C. & Berns, A. EMBO J. 3, 3215–3222 (1984).

    Article  Google Scholar 

  18. Leder, P. et al. Science 222, 765–771 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  19. Klein, G. & Klein, E. Immun. Today 6, 208–215 (1985).

    Article  CAS  PubMed  Google Scholar 

  20. Cory, S. Adv. Cancer Res. (in the press).

  21. Gillies, S. D., Morrison, S. L., Oi, V. T., Tonegawa, S. Cell 33, 717–728 (1983).

    Article  CAS  PubMed  Google Scholar 

  22. Banerji, J., Olson, L. & Schaffner, W. Cell 33, 729–740 (1983).

    Article  CAS  PubMed  Google Scholar 

  23. Neuberger, M.S. EMBO J. 2, 1373–1378 (1983).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Grosschedl, R. & Baltimore, D. Cell 41, 885–897 (1985).

    Article  CAS  PubMed  Google Scholar 

  25. Rabbitts, T. H., Hamlyn, P. & Baer, R. Nature 309, 592–597 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  26. Corcoran, L. M., Cory, S. & Adams, J. M. Cell 40, 71–79 (1985).

    Article  CAS  PubMed  Google Scholar 

  27. Queen, C. & Baltimore, D. Cell 33, 741–748 (1983).

    Article  CAS  PubMed  Google Scholar 

  28. Picard, D. & Schaffner, W. Nature 307, 80–82 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  29. Brinster, R. L., Chen, H. Y., Trumbauer, M. E., Yagle, M. K. & Palmiter, R. D. Proc. natn. Acad. sci. U.S.A. 82, 4438–4442 (1985).

    Article  ADS  CAS  Google Scholar 

  30. Land, H., Parada, L. & Weinberg, R. Nature 304, 596–602 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  31. Palmiter, R. D., Chen, H. Y. & Brinster, R. L. Cell 29, 701–710 (1982).

    Article  CAS  PubMed  Google Scholar 

  32. Palmiter, R. D., Norstedt, G., Gelinas, R. E., Hammer, R. E. & Brinster, R. L. Science 222, 809–814 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  33. Downes, T. M., Lingrel, J. B., Chen, H. Y., Brinster, R. L. & Palmiter, R. D. EMBO J. 4, 1715–1723 (1985).

    Article  Google Scholar 

  34. Abelson, H. T. & Rabstein, L. S. Cancer Res. 30, 2213–2222 (1970).

    CAS  PubMed  Google Scholar 

  35. Kemp, D. J., Harris, A. W., Cory, S. & Adams, J. M. Proc. natn. Acad. sci U.S.A. 77, 2876–2880 (1980).

    Article  ADS  CAS  Google Scholar 

  36. Kemp, D.J., Harris, A. W. & Adams, J.M. Proc. natn. Acad. sci. U.S.A. 77, 7400–7404 (1980).

    Article  ADS  CAS  Google Scholar 

  37. Alt, F. W., Rosenberg, N., Enea, V., Siden, E. & Baltimore, D. Molec. cell. Biol. 2, 386–400 (1982).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Kemp, D. J., Wilson, A., Harris, A. W. & Shortman, K. Nature 286, 168–170 (1980).

    Article  ADS  CAS  PubMed  Google Scholar 

  39. Nelson, K. J., Haimovich, J. & Perry, R. P. Molec. cell. Biol. 3, 1317–1332 (1983).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Rogers, J. et al. Cell 20, 303–312 (1980).

    Article  CAS  PubMed  Google Scholar 

  41. Reth, M. G. & Alt, F. W. Nature 312, 418–423 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  42. Van Ness, B. G. et al. Cell 27, 593–602 (1981).

    Article  CAS  PubMed  Google Scholar 

  43. Alt, F. W., Enea, V., Bothwell, A. L. M. & Baltimore, D. Cell 21, 1–12 (1980).

    Article  CAS  PubMed  Google Scholar 

  44. Lewis, S., Rosenberg, N., Alt, F. & Baltimore, D. Cell 30, 807–816 (1982).

    Article  CAS  PubMed  Google Scholar 

  45. Bernard, O., Cory, S., Gerondakis, S., Webb, E. & Adams, J. M. EMBO J. 2, 2375–2383 (1983).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Adams, J. M., Gerondakis, S., Webb, E., Corcoran, L. M. & Cory, S. Proc. natn. Acad. sci. U.S.A. 80, 1982–1986 (1983).

    Article  ADS  CAS  Google Scholar 

  47. Kelley, K., Cochran, B. H., Stiles, C. D. & Leder, P. Cell 35, 603–610 (1983).

    Article  Google Scholar 

  48. Nishikura, K. et al. Proc. natn. Acad. sci. U.S.A 80, 4822–4826 (1983).

    Article  ADS  CAS  Google Scholar 

  49. Nishikura, K., Erikson, J., Ar-Rushdi, A., Huebner, K. & Croce, C. M. Proc. natn. Acad. sci. U.S.A. 82, 2900–2904 (1985).

    Article  ADS  CAS  Google Scholar 

  50. Zaller, D. & Eckhardt, L. Proc. natn. Acad. sci. U.S.A. 82, 5088–5092 (1985).

    Article  ADS  CAS  Google Scholar 

  51. Wanebo, H. J., Gallmeier, W. M., Boyse, E. A. & Old, L. J. Science 154, 901–903 (1966).

    Article  ADS  CAS  PubMed  Google Scholar 

  52. Glanville, N., Durnam, D. & Palmiter, R. D. Nature 292, 267–269 (1981).

    Article  ADS  CAS  PubMed  Google Scholar 

  53. Max, E., Maizel, J. & Leder, P. J. biol. Chem. 256, 5116–5120 (1981).

    CAS  PubMed  Google Scholar 

  54. Gonda, T., Sheiness, D. & Bishop, J. M. Molec. cell. Biol. 2, 617–624 (1982).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Thomas, P. Proc. natn. Acad. sci. U.S.A. 77, 5201–5205 (1980).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Walter and Eliza Hall Institute of Medical Research, PO Royal Melbourne Hospital, Victoria, 3050, Australia

    J. M. Adams, A. W. Harris, L. M. Corcoran, W. S. Alexander & S. Cory

  2. School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA

    C. A. Pinkert & R. L. Brinster

  3. Howard Hughes Medical Institute, University of Washington, Seattle, Washington, 98195, USA

    R. D. Palmiter

Authors
  1. J. M. Adams
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. W. Harris
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. A. Pinkert
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. L. M. Corcoran
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. W. S. Alexander
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S. Cory
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. R. D. Palmiter
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. R. L. Brinster
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Adams, J., Harris, A., Pinkert, C. et al. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 318, 533–538 (1985). https://doi.org/10.1038/318533a0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/318533a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing