Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Peripheral neuropathies, hepatocellular carcinomas and islet cell adenomas in transgenic mice

Nature volume 316, pages 461–463 (1985)Cite this article

Abstract

The ability to introduce foreign DNA into the genome of mice offers unique opportunities to produce new models of disease processes. Recent experiments have shown that integration and expression of simian virus 40 (SV40) T antigen genes1 and the murine mammary tumour virus (MMTV)–myc genes2 in transgenic mice can lead to the development of neoplasia in a remarkably tissue-specific manner. In the case of SV40-bearing mice, tumours consistently develop in the choroid plexus1. In the accompanying paper, we show that the 72-base pair (bp) enhancer in the SV40 genome is instrumental in directing tumorigenesis to the choroid plexus3. However, when the enhancer is deleted from a construction also containing the metallothionein-human growth hormone fusion gene (SVΔe-MGH), an entirely new pattern of pathology results. The present report focuses on transgenic mice carrying this construct; they develop demyelinating peripheral neuropathies, hepatocellular carcinomas and islet cell adenomas.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Brinster, R. L. et al. Cell 37, 367–379 (1984).

    Article  CAS  Google Scholar 

  2. Stewart, T. A., Pattengale, P. K. & Leder, P. Cell 38, 627–637 (1984).

    Article  CAS  Google Scholar 

  3. Palmiter, R. D., Chen, H. Y., Messing, A. & Brinster, R. L. Nature This issue.

  4. Dyck, P. J., Karnes, J., Lais, A., Lofgren, E. P. & Stevens, J. C. in Peripheral Neuropathy (eds Dyck, P. J., Thomas, P. K., Lambert, E. H. & Bunge, R.) 760–870 (Saunders, Philadelphia, (1984).

    Google Scholar 

  5. Jaspan, J. B., Wollman, R. L., Bernstein, L. & Rubenstein, A. H. Medicine 61, 33–44 (1982).

    Article  CAS  Google Scholar 

  6. Sidenius, P. & Jakobsen, J. Diabetes 32, 383–386 (1983).

    Article  CAS  Google Scholar 

  7. Palmiter, R. D., Wilkie, T. M., Chen, H. Y. & Brinster, R. L. Cell 36, 869–877 (1984).

    Article  CAS  Google Scholar 

  8. Bray, G. M., Rasminsky, M. & Aguayo, A. J. A. Rev. Neurosci. 4, 127–162 (1981).

    Article  CAS  Google Scholar 

  9. Ayers, M. M. & Anderson, R. M. Acta neuropath. 25, 54–70 (1973).

    Article  CAS  Google Scholar 

  10. Low, P. A. & McLeod, J. G. J neural. Sci. 26, 565–574 (1975).

    Article  CAS  Google Scholar 

  11. Dyck, P. J. & Gomez, M. R. Mayo Clin. Proc. 43, 280–296 (1968).

    CAS  PubMed  Google Scholar 

  12. Dyck, P. J. in Peripheral Neuropathy (eds Dyck, P. J., Thomas, P. K., Lambert, E. H. & Bunge, R.) 1630–1634 (Saunders, Philadelphia, (1984).

    Google Scholar 

  13. Zu Rhein, G. M. & Chou, S. Science 148, 1477–1479 (1965).

    Article  ADS  CAS  Google Scholar 

  14. Padgett, B. L., Zu Rhein, G. M., Walker, D. L., Eckroade, R. J. & Dessel, B. H. Lancet i, 1257–1260 (1971).

  15. Weiner, L. P. et al. New Engl. J. Med. 286, 385–390 (1972).

    Article  CAS  Google Scholar 

  16. Johnson, R. T. in Polyomaviruses and Human Neurological Diseases (eds Sever J. L. & Madden, D. L.) 183–190 (Liss, New York, (1983).

    Google Scholar 

  17. Farwell, J. R., Dohrmann, G. J. & Flannery, J. T. J. Neurosurg. 61, 657–664 (1984).

    Article  CAS  Google Scholar 

  18. Palmiter, R. D., Chen, H. Y. & Brinster, R. L. Cell 29, 701–710 (1982).

    Article  CAS  Google Scholar 

  19. Palmiter, R. D. et al. Nature 300, 611–615 (1982).

    Article  ADS  CAS  Google Scholar 

  20. Palmiter, R. D., Norstedt, G., Gelinas, R. E., Hammer, R. E. & Brinster, R. L. Science 222, 809–814 (1983).

    Article  ADS  CAS  Google Scholar 

  21. Friede, R. L. & Samorajski, T. J. comp. Neurol. 130, 223–232 (1967).

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. Albee Messing

    Present address: School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, 53706, USA

Authors and Affiliations

  1. Division of Neuropathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, 19104, USA

    Albee Messing

  2. Laboratory of Reproductive Physiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA

    Howard Y. Chen & Ralph L. Brinster

  3. Howard Hughes Medical Institute, Department of Biochemistry, University of Washington, Seattle, Washington, 98195, USA

    Richard D. Palmiter

Authors
  1. Albee Messing
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Howard Y. Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Richard D. Palmiter
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ralph L. Brinster
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Messing, A., Chen, H., Palmiter, R. et al. Peripheral neuropathies, hepatocellular carcinomas and islet cell adenomas in transgenic mice. Nature 316, 461–463 (1985). https://doi.org/10.1038/316461a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/316461a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing