Abstract
The human T-cell leukaemia/lymphoma virus (HTLV)1 is an exogenous retrovirus which has been associated with adult T-cell leukaemia/lymphoma (ATL)2. This malignancy of T lymphocytes is endemic to southern Japan3, the West Indies4, and to a lesser extent, the Middle East, Central Africa and the southeastern United States5. ATL cells from patients of diverse geographical origins have been found to be infected with HTLV-1 (ref. 6). HTLV is normally tropic for mature T lymphocytes1, especially those expressing the helper-inducer surface antigen phenotype7 (OKT4 or Leu-3-positive), and the neoplastic T cells infected with HTLV generally express receptors for T-cell growth factor8 (detected by reactivity with anti-Tac antibody9). However, we report here the isolation of a HTLV-infected B-lymphocyte clone from the peripheral blood of a patient with ATL. This clone is cytogenetically normal and is not infected with Epstein-Barr virus (EBV). Co-culture of cells from this clone with cord blood lymphocytes resulted in transmission of HTLV and the immortalization of either T or B lymphocytes. These results suggest that HTLV may be associated with a broader range of host cells than previously recognized.
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Longo, D., Gelmann, E., Cossman, J. et al. Isolation of HTLV-transformed B-lymphocyte clone from a patient with HTLV-associated adult T-cell leukaemia. Nature 310, 505–506 (1984). https://doi.org/10.1038/310505a0
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DOI: https://doi.org/10.1038/310505a0
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