Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

A novel human lymphokine that inhibits haematopoietic progenitor cell proliferation

Nature volume 309, pages 166–168 (1984)Cite this article

Abstract

T lymphocytes in culture synthesize and secrete a variety of factors1–6 that activate and guide the differentiation3,4, replication5 and maturation5 of haematopoietic cells in vitro. Malignant T-cell lines as well as T-cell hybridomas producing several of these factors have been established5–13. We report here a factor produced by a human cell line that exerts a potent inhibitory effect on the growth of bone marrow progenitor cells. The properties of this factor, which we have termed colony-inhibiting lymphokine (CIL), differ from other inhibitors of haematopoietic progenitor cell proliferation, but resemble those of a T-cell-derived factor causally linked with some cases of severe aplastic anaemia in humans14. Sensitivity of cells to this factor appears to correlate positively with expression of HLA-DR surface antigens.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it

$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

References

  1. Chervenick, P. A. & LoBuglio, A. F. Science 178, 169–170 (1972).

    Article  ADS  Google Scholar 

  2. Porter, J. W. & Metcalf, D. J. J. Immun. 112, 504–510 (1974).

    Google Scholar 

  3. Olsson, J., Olofsson, T. & Mauritzon, N. J. natn. Cancer Inst. 67, 1225–1231 (1981).

    CAS  Google Scholar 

  4. Iscove, N. N., Rotsch, C. A., Williams, N. & Guilbert, L. J. J. cell. Physiol. (Suppl.) 1, 65–73 (1982).

    Article  CAS  Google Scholar 

  5. Lernhardt, W., Corbel, C., Wall, R. & Melchers, F. Nature 300, 355–356 (1982).

    Article  CAS  ADS  PubMed  Google Scholar 

  6. Waksman, B. H. in The Biology of the Lymphokines (eds Cohen, S., Dick, E. & Oppenheim, J. J.) 585–613 (Academic, New York, 1979).

    Book  Google Scholar 

  7. DeFreitas, E. et al., Proc. natn. Acad. Sci. U.S.A. 79, 6646–6650 (1982).

    Article  CAS  ADS  Google Scholar 

  8. Gillis, S. & Watson, J. J. exp. Med. 152, 1709–1719 (1980).

    Article  CAS  PubMed  Google Scholar 

  9. DiPersio, J. F., Brennan, J. K., Lightman, M. & Speiser, B. L. Blood 51, 507–519 (1978).

    CAS  Google Scholar 

  10. Von Boehmer, H., Haas, W., Kohler, G., Melchers, F. & Zeuthen, J. Curr. Topics Microbiol. Immun. 100, 5–320 (1982).

    Google Scholar 

  11. Grillot-Courvalin, C., Brovet, J. C., Berger, R. & Bernheim, A. Nature 292, 844–845 (1981).

    Article  CAS  ADS  PubMed  Google Scholar 

  12. Kobayashi, Y., Asada, M., Higuchi, M. & Osawa, T. J. Immun. 128, 2714–2719 (1982).

    CAS  PubMed  Google Scholar 

  13. Okada, M., Yoshimura, N., Kaieda, T., Yamamura, Y. & Kishimoto, T. Proc. natn. Acad. Sci. U.S.A. 78, 7717–7726 (1981).

    Article  CAS  ADS  Google Scholar 

  14. Bacigalupo, A. et al. J. Immun. 125, 1449–1452 (1980).

    CAS  PubMed  Google Scholar 

  15. Trucco, M., Garotta, G., Stocker, J. W. & Ceppellini, R. Immun. Rev. 47, 219–252 (1979).

    Article  CAS  PubMed  Google Scholar 

  16. Foung, S., Sasaki, D. T., Grumet, F. C. & Engleman, E. Proc. natn. Acad. Sci. U.S.A. 79, 7484–7489 (1982).

    Article  CAS  ADS  Google Scholar 

  17. Iscove, N. N., Senn, J. S., Till, J. E. & McCulloch, E. A. Blood 37, 1–5 (1971).

    CAS  PubMed  Google Scholar 

  18. Johnson, G. R., Dresch, C. & Metcalf, D. Blood 50, 823–831 (1977).

    CAS  PubMed  Google Scholar 

  19. Ferrero, D. et al. Proc. natn. Acad. Sci. U.S.A. 80, 4114–4119 (1983).

    Article  CAS  ADS  Google Scholar 

  20. Ferrero, D. & Rovera, G. in Clinics in Hematology (ed. McCulloch, E. A.) Vol. 13, 461–487 (W. B. Saunders, London, 1984).

    Google Scholar 

  21. Pelus, L. M. J. clin. Invest. 70, 568–578 (1982).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Broxmeyer, H. E. J. clin. Invest. 69, 632–642 (1982).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Lu, L., Broxmeyer, H. E., Meyers, P. A., Moore, M. A. & Thaler, H. T. Blood 61, 250–256 (1983).

    CAS  PubMed  Google Scholar 

  24. Reinherz, E. L. & Schlossman, S. F. Cell 19, 821–826 (1980).

    Article  CAS  PubMed  Google Scholar 

  25. Broxmeyer, H. E., Shithyman, A., Eger, R. R., Meyers, P. A. & deSousa, M. J. exp. Med. 148, 1052–1063 (1978).

    Article  CAS  PubMed  Google Scholar 

  26. Kurland, J., Backman, R., Broxmeyer, H. E. Moore, M. Science 199, 552–553 (1978).

    Article  CAS  ADS  PubMed  Google Scholar 

  27. Broxymeyer, H. E., Bognati, T., Dorner, M. H. & deSousa, M. J. exp. Med. 153, 1426–1444 (1981).

    Article  Google Scholar 

  28. Greenberg, P. L. & Mosny, S. A. Cancer Res. 37, 1794–1799 (1977).

    CAS  PubMed  Google Scholar 

  29. Santoli, D. et al., J. Immun. 126, 1274–1278 (1981).

    CAS  PubMed  Google Scholar 

  30. Bacigalupo, A. et al. Blood 57, 491–496 (1981).

    CAS  PubMed  Google Scholar 

  31. Ash, R. C., Detrick, R. A. & Zanjani, E. D. Blood 58, 309–316 (1981).

    CAS  PubMed  Google Scholar 

  32. Tepperman, A. D., Curtis, J. E. & McCulloch, E. A. Blood 44, 659–669 (1974).

    CAS  PubMed  Google Scholar 

Download references

Author information

Author notes

  1. Dario Ferrero

    Present address: Department of Haematology, University of Turin, Ospedale S. Giovanni, Torino, Italy

Authors and Affiliations

  1. Wistar Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia, Pennsylvania, 19104, USA

    Massimo Trucco, Giovanni Rovera & Dario Ferrero

Authors
  1. Massimo Trucco
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Giovanni Rovera
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Dario Ferrero
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Trucco, M., Rovera, G. & Ferrero, D. A novel human lymphokine that inhibits haematopoietic progenitor cell proliferation. Nature 309, 166–168 (1984). https://doi.org/10.1038/309166a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/309166a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing