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Interleukin-3 supports growth of mouse pre-B-cell clones in vitro

Nature volume 309, pages 126–131 (1984)Cite this article

Abstract

Study of the differentiation of immunoglobulin-producing B lymphocytes has been hampered by the inability to maintain homogeneous populations of precursor cells in vitro. We describe here that interleukin-3 supports the growth of freshly isolated fetal liver pre-B cells and the long-term culture of interleukin-3 dependent pre-B-cell clones that can be induced to mature into antibody secreting cells in vitro.

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Authors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstrasse 487, CH-4005, Basel, Switzerland

    Ronald Palacios, Geoffrey Henson, Michael Steinmetz & John P. McKearn

Authors
  1. Ronald Palacios
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  2. Geoffrey Henson
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  3. Michael Steinmetz
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  4. John P. McKearn
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Palacios, R., Henson, G., Steinmetz, M. et al. Interleukin-3 supports growth of mouse pre-B-cell clones in vitro. Nature 309, 126–131 (1984). https://doi.org/10.1038/309126a0

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