Abstract
Natural killer (NK) activity1 against tumour and virus-infected target cells is shown by a subpopulation of peripheral blood mononuclear leukocytes with the morphological features of large granular lymphocytes (LGL)2. The lineage of human LGL is still controversial, as they display surface markers of both T lymphocytes and myelomonocytic cells3. LGL have recently been reported to produce lymphokines such as interleukin-2 (IL-2)4,5 and α- as well as γ-interferons6, functions associated mainly with T cells. To determine whether cytokines associated with other cell lineages are also produced by LGL, we examined whether they might produce a myelomonocyte-associated cytokine such as interleukin-1 (IL-1). IL-1 is a 12–18,000 molecular weight (MW) lymphokine produced by a variety of cell types such as monocytes7, keratinocytes8 and a human dendritic cell line9, which plays a crucial role in immunoregulation and inflammation10,11. Moreover, IL-1 has recently been reported to act synergistically with IL-2 and interferons in boosting LGL-mediated NK activity12. We now show that a subset of highly purified human LGL with NK activity can be stimulated to secrete a soluble factor with the biochemical and biological characteristics of human IL-1.
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Scala, G., Allavena, P., Djeu, J. et al. Human large granular lymphocytes are potent producers of interleukin-1. Nature 309, 56–59 (1984). https://doi.org/10.1038/309056a0
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DOI: https://doi.org/10.1038/309056a0
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