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Molecular conformations in surfactant micelles

Nature volume 309, pages 42–45 (1984)Cite this article

Abstract

For more than half a century, the cornerstone to our understanding of molecular organization in amphiphilic aggregates has been Langmuir's principle of differential solubility1, according to which the polar heads of amphiphilic molecules dissolve in water whereas the hydrocarbon tails cluster in a core in order to minimize solvent contact2–5. This view has recently been challenged; much spectroscopic data6–17 have been construed11–17 to indicate significant penetration of water into the cores of micelles. Here various models of micellar structure are critically tested against results from NMR and recent small-angle neutron scattering (SANS) experiments. Molecular organization is found to be the consequence of Langmuir's principle and of the packing requirements imposed by steric constraints among chain molecules at interfaces. The evidence is unambiguous that these cores are virtually devoid of internal water.

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References

  1. Dill, K. A. in Surfactants in Solution Vol. 1 (eds Mittal, K. L. & Lindman, B.) 307–320 (Plenum, New York, 1983).

    Google Scholar 

  2. Hartley, G. S. Aqueous Solutions of Paraffin Chain Salts (Hermann, Paris, 1936).

    Google Scholar 

  3. Tanford, C. The Hydrophobic Effect 2nd edn (Wiley-Interscience, New York, 1980).

    Google Scholar 

  4. Lindman, B. & Wennerstrom, H. Topics Curr. Chem. 87, 1–81 (1980).

    Article  CAS  Google Scholar 

  5. Israelachvili, J. N., Marcelja, S. & Horn, R. G. Q. Rev. Biophys. 13, 121–200 (1980).

    Article  CAS  Google Scholar 

  6. Russell, J. C., Whitten, D. G. & Braun, A. M. J. Am. chem. Soc. 103, 3219–3220 (1981).

    Article  CAS  Google Scholar 

  7. Russell, J. C. & Whitten, D. G. J. Am. chem. Soc. 104, 5937–5942 (1982).

    Article  CAS  Google Scholar 

  8. Rodgers, M. A. J. J. phys. Chem. 85, 3372–3374 (1981).

    Article  CAS  Google Scholar 

  9. Reed, W., Politi, M. J. & Fendler, J. H. J. Am. chem. Soc. 103, 4591–4593 (1981).

    Article  CAS  Google Scholar 

  10. Fadnavis, N. & Engberts, J. B. F. N. J. org. Chem. 47, 152–154 (1982).

    Article  CAS  Google Scholar 

  11. Menger, F. M. Acc. chem. Res. 12, 111–117 (1979).

    Article  CAS  Google Scholar 

  12. Menger, F. M. & Bonicamp, J. M. J. Am. chem. Soc. 103, 2140–2141 (1981).

    Article  CAS  Google Scholar 

  13. Menger, F. M. & Boyer, B. J. J. Am. chem. Soc. 102, 5936–5938 (1980).

    Article  CAS  Google Scholar 

  14. Menger, F. M., Yoshinaga, H., Venkatasubban, K. S. & Das, A. R. J. org. Chem. 46, 415–419 (1981).

    Article  CAS  Google Scholar 

  15. Turro, N. J. & Okubo, T. J. Am. chem. Soc. 103, 7224–7228 (1981).

    Article  CAS  Google Scholar 

  16. Martens, F. M. & Verhoeven, J. W. J. phys. Chem. 85, 1773–1777 (1981).

    Article  CAS  Google Scholar 

  17. Menger, F. M., Jerkunica, J. M. & Johnston, J. C. J. Am. chem. Soc. 100, 4676–4678 (1978).

    Article  CAS  Google Scholar 

  18. Bendedouch, D., Chen, S. H. & Koehler, W. C. J. phys. Chem. 87, 153–159 (1983).

    Article  CAS  Google Scholar 

  19. Bendedouch, D., Chen, S. H. & Koehler, W. C. J. phys. Chem. 87, 2621–2628 (1983).

    Article  CAS  Google Scholar 

  20. Kotlarchyk, M. & Chen, S. H. J. chem. Phys. 79, 2461–2469 (1983).

    Article  ADS  CAS  Google Scholar 

  21. Dill, K. A. & Flory, P. J. Proc. natn. Acad. Sci. U.S.A. 77, 3115–3119 (1980).

    Article  ADS  CAS  Google Scholar 

  22. Dill, K. A. & Flory, P. J. Proc. natn. Acad. Sci. U.S.A. 78, 676–680 (1981).

    Article  ADS  CAS  Google Scholar 

  23. Cantor, C. R. & Schimmel, P. R. in Biophysical Chemistry Vol. 3, 1346 (Freeman, San Francisco, 1980).

    Google Scholar 

  24. Atkins, P. W. Physical Chemistry 2nd edn., 845 (Freeman, San Francisco, 1982).

    Google Scholar 

  25. Cabane, B. J. Phys., Paris 42, 847–859 (1981).

    Article  CAS  Google Scholar 

  26. Dill, K. A. J. phys. Chem. 86, 1498–1500 (1982).

    Article  CAS  Google Scholar 

  27. Mely, B., Charvolin, J. & Keller, P. Chem. Phys. Lipids 15, 161–173, (1975).

    Article  CAS  Google Scholar 

  28. Kalyanasundaram, K. & Thomas, J. K. J. phys. Chem. 80, 1462–1473 (1976).

    Article  CAS  Google Scholar 

  29. Simon, S. A., Stone, W. L. & Busto-Latorre, P. Biochim. biophys. Acta 468, 378–388 (1977).

    Article  CAS  Google Scholar 

  30. Czarniecki, M. F. & Breslow, R. J. Am. chem. Soc. 101, 3675–3676 (1979).

    Article  CAS  Google Scholar 

  31. Dill, K. A. & Cantor, R. S. Macromolecules 17, 380–384 (1984).

    Article  ADS  CAS  Google Scholar 

  32. Cantor, R. S. & Dill, K. A. Macromolecules 17, 384–388 (1984).

    Article  ADS  CAS  Google Scholar 

  33. Gruen, D. W. R. in Surfactants in Solution Vol. 1 (eds Mittal, K. L. & Lindman, B.) 279–309 (Plenum, New York, 1984).

    Book  Google Scholar 

  34. Gruen, D. W. R. J. Coll. Int. Sci. 84, 281–283 (1981).

    Article  ADS  CAS  Google Scholar 

  35. Flory, P. J. Statistical Mechanics of Chain Molecules (Wiley-Interscience, New York, 1969).

    Book  Google Scholar 

  36. Busico, V. & Vacatello, M. Molec. Cryst. Liquid Cryst. 97, 195–207 (1983).

    Article  CAS  Google Scholar 

  37. Seelig, J. Q. Rev. Biophys. 10, 353–418 (1977).

    Article  CAS  Google Scholar 

  38. Cabane, B. in Surfactants in Solution Vol. 1 (eds Mittal, K. L. & Lindman, B.) 373–404 (Plenum, New York, 1984).

    Book  Google Scholar 

  39. Svens, B. & Rosenholm, B. J. Coll. Int. Sci. 44, 495–504 (1973).

    Article  ADS  CAS  Google Scholar 

  40. Ganesh, K. N., Mitra, P. & Balasubramanian, D. in Surfactants in Solution Vol. 1 (eds Mittal, K. L. & Lindman, B.) 599–612 (Plenum, New York, 1984).

    Book  Google Scholar 

  41. Ganesh, K. N., Mitra, P. & Balasubramanian, D. J. phys. Chem. 86, 4291–4293 (1982).

    Article  CAS  Google Scholar 

  42. Zachariasse, K. A. & Kozankiewicz, G. in Surfactants in Solution Vol. 1 (eds Mittal, K. L. & Lindman, B.) 565–585 (Plenum, New York, 1984).

    Book  Google Scholar 

  43. Muller, N. & Simsohn, H. J. phys. Chem. 75, 942–945 (1971).

    Article  CAS  Google Scholar 

  44. Chandler, D., Weeks, J. D. & Andersen, H. C. Science 220, 787–794 (1983).

    Article  ADS  CAS  Google Scholar 

  45. Menger, F. M. & Doll, D. W. J. Am. chem. Soc. 106, 1109–1113 (1984).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Departments of Pharmaceutical Chemistry and Pharmacy, University of California, San Francisco, California, 94143, USA

    Ken A. Dill, Daniel E. Koppel & Robert S. Cantor

  2. Molecular Design Ltd, 23 Hayward, California, 94541, USA

    James D. Dill

  3. Department of Nuclear Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Dalila Bendedouch & Sow-Hsin Chen

Authors
  1. Ken A. Dill
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  2. Daniel E. Koppel
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  3. Robert S. Cantor
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  4. James D. Dill
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  5. Dalila Bendedouch
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  6. Sow-Hsin Chen
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Dill, K., Koppel, D., Cantor, R. et al. Molecular conformations in surfactant micelles. Nature 309, 42–45 (1984). https://doi.org/10.1038/309042a0

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