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A minor transplantation antigen detected by MHC-restricted cytotoxic T lymphocytes during graft-versus-host disease

Nature volume 302, pages 159–161 (1983)Cite this article

Abstract

Transplantation of bone marrow can give rise to graft-versus-host desease when donor T lymphocytes; mismatched with the host for major histocompatability (MHC) antigens, become sensitized and attack host tissues. However, graft-versus-host desease can also arise between donor and host with compatible MHC antigens but mismatched for a minor histocompatability antigen1–3. We report here on the occurrence of severe acute graft-versus-host disease in a male patient with acute myeloid leukaemia who had received bone marrow matched for MHC (HLA) antigens from his sister. Strong cytotoxicity of the post-transplantation (that is, donor) lymphocytes against the patient's pretransplantation lymphocytes was found. Thus, the transplanted lymphocytes differed in a non-HLA antigen from the patient. The possible role of this strong cytotoxic minor histocompatability antigen in the development of graft-versus-host disease in man is being evaluated. Furthermore, with the use of cytotoxic T-cell lines, derived from the patient's 6 day effector cells, we are now able to type for it before grafting.

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Authors and Affiliations

  1. Department of Immunohaematology and Blood Bank, University Hospital Leiden, Rijnsburgerweg 10, 2133 AA, Leiden, The Netherlands

    E. Goulmy, J. W. Gratama, E. Blokland & J. J. van Rood

  2. Isolation Pavilion, University Hospital Leiden, Rijnsburgerweg 10, 2133 AA, Leiden, The Netherlands

    F. E. Zwaan

Authors
  1. E. Goulmy
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  2. J. W. Gratama
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  3. E. Blokland
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  4. F. E. Zwaan
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  5. J. J. van Rood
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Goulmy, E., Gratama, J., Blokland, E. et al. A minor transplantation antigen detected by MHC-restricted cytotoxic T lymphocytes during graft-versus-host disease. Nature 302, 159–161 (1983). https://doi.org/10.1038/302159a0

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