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Mechanism of activation of a human oncogene

Abstract

The oncogene of the human EJ bladder carcinoma cell lines arose via alteration of a cellular proto-oncogene. Experiments are presented that localize the genetic lesion that led to activation of the oncogene. The lesion has no affect on levels of expression of the oncogene. Instead, it affects the structure of the oncogene-encoded protein.

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Tabin, C., Bradley, S., Bargmann, C. et al. Mechanism of activation of a human oncogene. Nature 300, 143–149 (1982). https://doi.org/10.1038/300143a0

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