Abstract
Members of three distinct classes of animal virus have been associated with naturally occurring neoplasias in man: Epstein–Barr virus (EBV)1, a DNA virus belonging to herpesvirus group, papillomavirus2, and a novel human RNA (retro) virus3–8, human T-cell leukaemia virus or adult T-cell leukaemia (ATL) virus. We have established seven continuous cell lines from ATL patients and 0.1–7% of these cells consistently express ATL-specific antigens (ATLA)8,9. EBV-associated nuclear antigen (EBNA)10 is also found in more than 90% of these cells. We have cloned cells from two of these lines and show here that both ATLA and EBNA were present in the same B-cell clone carrying surface immunoglobulin (sIg).
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Yamamoto, N., Matsumoto, T., Koyanagi, Y. et al. Unique cell lines harbouring both Epstein–Barr virus and adult T-cell leukaemia virus, established from leukaemia patients. Nature 299, 367–369 (1982). https://doi.org/10.1038/299367a0
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DOI: https://doi.org/10.1038/299367a0
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