Abstract
The evidence for fluid secretion by the kidneys of teleosts is indirect1–4. By using in vitro microperfusion of renal tubules5, we have observed fluid secretion in the proximal tubule of the winter flounder Pseudopleuronectes americanus. Unlike the isosmotic fluid transfer across most vertebrate proximal tubules, the secreted fluid in this teleost could be hyperosmotic to the bathing medium. More importantly, fluid secretion was not dependent on the transport of Mg, S or organic ions4–6, but appeared to be driven by NaCl, the major solute in the secreted fluid. This mechanism of NaCl-dependent fluid secretion has been previously undetected because renal clearances showed the overall net reabsorption of NaCl and water4,7.
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Beyenbach, K. Direct demonstration of fluid secretion by glomerular renal tubules in a marine teleost. Nature 299, 54–56 (1982). https://doi.org/10.1038/299054a0
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DOI: https://doi.org/10.1038/299054a0
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