Abstract
From differences in the ability of fragments of the λ repressor to protect operator bases from chemical modification we suggest that the first few N-terminal residues of the λ repressor form an extended arm that reaches around the back of the DNA helix when repressor binds to the operator.
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References
Sauer, R. T., Pabo, C. O., Meyer, B. J., Ptashne, M. & Backman, K. C. Nature 279, 396–400 (1979).
Pabo, C. O. & Lewis, M. Nature 298, 443–447 (1982).
Pabo, C. O., Sauer, R. T., Sturtevant, J. M. & Ptashne, M. Proc. natn. Acad. Sci. U.S.A. 76, 1608–1612 (1979).
Sauer, R. T. & Anderegg, R. Biochemistry 17, 1092–1100 (1978).
Gilbert, W., Maxam, A. & Mirzabekov, A. D. Alfred Benson Symp. 9, 139–148 (1976).
Johnson, A. D. J. molec. Biol. (in the press).
Maniatis, T. & Ptashne, M. Proc. natn. Acad. Sci. U.S.A. 70, 1531–1535 (1973).
Flashman, S. M. thesis, Harvard Univ. (1976).
Sauer, R. T. thesis, Harvard Univ. (1979).
Huber, R. Trends biochem. Sci. 4, 271–276 (1979).
Ptashne, M. et al. Cell 19, 1–11 (1980).
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Pabo, C., Krovatin, W., Jeffrey, A. et al. The N-terminal arms of λ repressor wrap around the operator DNA. Nature 298, 441–443 (1982). https://doi.org/10.1038/298441a0
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DOI: https://doi.org/10.1038/298441a0
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