Abstract
The lethality of tumours is determined largely by their ability to metastasize to distant sites. Once metastasis has occurred, eradication of the tumour cells from the body becomes difficult or impossible. Although the steps involved in tumour metastasis have been well documented (for review see refs 1–3), the cellular parameters that influence the tendency of tumours to metastasize have been more difficult to define4–7, and the underlying genetic determinants of metastatic potential are not known. We are studying the metastasis of tumours induced in hamsters by simian virus 40 (SV40). We show here that tumours induced by a viral mutant (d1884) in the small T antigen gene tend to metastasize, whereas tumours induced by wild-type SV40 rarely do so. Thus, we have a well defined system in which the underlying genetic differences in the transforming viruses are known and in which we may be able to correlate these differences with cellular parameters that determine tumour metastasis.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Poste, G. & Fidler, I. J. Nature 283, 139–146 (1980).
Fidler, I. J., Gersten, D. M. & Hart, I. R. Adv. Cancer Res. 28, 149–250 (1978).
Roos, E. & Dingemans, K. P. Biochim. biophys. Acta 560, 135–166 (1979).
Fidler, I. J. Nature new Biol. 242, 148–149 (1973).
Fidler, I. J. Cancer Res. 35, 218–224 (1975).
Fidler, I. J. & Nicolson, G. L. Isr. J. med. Sci. 14, 38–50 (1977).
Nicolson, G. L. & Winkelhake, J. L. Nature 255, 230–232 (1975).
Sleigh, M., Topp, W. C., Hanich, R. & Sambrook, J. F. Cell 14, 79–88 (1978).
Frisque, R. J., Rifkin, D. B. & Topp, W. C. Cold Spring Harb. Symp. quant. Biol. 44, 325–331 (1980).
Seif, R. & Martin, R. G. J. Virol. 31, 350–359 (1979).
Lewis, A. M. & Martin, R. G. Proc. natn. Acad. Sci. U.S.A. 76, 4299–4302 (1979).
Topp, W. C., Rifkin, D. B. & Sleigh, M. J. Virology 111, 341–350 (1981).
Botchan, M., Topp, W. & Sambrook, J. Cell 9, 269–287 (1976).
Wahl, G. M., Stern, M. & Stark, G. R. Proc. natn. Acad. Sci. U.S.A. 76, 3683–3687 (1979).
Deichman, G. I. & Kluchareva, T. E. J. natn. Cancer Inst. 36, 647–655 (1966).
Shenk, T., Carbon, J. & Berg, P. J. Virol. 18, 664–671 (1976).
Thimmappaya, B. & Shenk, T. J. Virol. 30, 668–673 (1979).
Robb, J. A. & Huebner, K. Expl. Cell Res. 81, 120–126 (1973).
Hirt, B. J. molec. Biol. 26, 365–369 (1967).
Botchan, M., McKenna, G. & Sharp, P. A. Cold Spring Harb. Symp. quant. Biol. 38, 383–395 (1973).
Blin, N. & Stafford, D. W. Nucleic Acids Res. 3, 2303–2308 (1976).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dixon, K., Ryder, BJ. & Burch-Jaffe, E. Enhanced metastasis of tumours induced by a SV40 small T deletion mutant. Nature 296, 672–675 (1982). https://doi.org/10.1038/296672a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/296672a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.