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The role of protein phosphorylation in neural and hormonal control of cellular activity

Nature volume 296, pages 613620 (15 April 1982) | Download Citation

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Abstract

Protein phosphorylation is now recognized to be the major general mechanism by which intracellular events in mammalian tissues are controlled by external physiological stimuli. However, only recently has the idea that different cellular functions are controlled by common protein kinases and protein phosphatases started to gain widespread acceptance. Thus there is an integrated network of regulatory pathways, mediated by phosphorylation–dephosphorylation, that allows diverse cellular events to be coordinated by neural and hormonal stimuli. The evidence that supports this concept is reviewed, with emphasis on the role of protein phosphorylation in enzyme regulation.

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  1. Department of Biochemistry, University of Dundee, Dundee DD1 4HN, UK

    • Philip Cohen

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