Abstract
Proviruses of avian leukosis virus (ALV) are located in the vicinity of a putative cellular oncogene (c-myc) in ALV-induced bursal lymphomas. Enhanced expression of c-myc occurs in association with proviruses found in any of three configurations: (I) on the 5′ side (‘upstream’) of c-myc in the same transcriptional orientation; (II) on the 3′ side (‘downstream’) of c-myc in the same orientation; (III) upstream, in the transcriptional orientation opposite to that of c-myc. Thus, activation of adjacent cellular genes by retroviral DNA can involve mechanisms other than provision of a transcriptional promoter.
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Payne, G., Bishop, J. & Varmus, H. Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas. Nature 295, 209–214 (1982). https://doi.org/10.1038/295209a0
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DOI: https://doi.org/10.1038/295209a0
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