Abstract
Cyclic AMP1 is known to mediate actions of various hormones and neurotransmitters in a variety of cells2–5. Its physiological role, however, in the transmitter release mechanism of vertebrate synapses is still controversial6–9. We report here evidence for the sustained, acceleratory effects of adrenaline and dibutyryl cyclic AMP on transmitter release in bullfrog sympathetic ganglia. The amplitude and quantal content of the fast excitatory postsynaptic potential (e.p.s.p.) and the frequency of miniature excitatory postsynaptic potential (m.e.p.s.p.) increased markedly for a long time after pretreatment with adrenaline or dibutyryl cyclic AMP. These results suggest a significant modulatory role for adrenaline, presumably linked with a cyclic AMP system, in the transmitter release mechanism, which may serve as a mechanism for neuronal plasticity in the peripheral autonomic nervous system.
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Kuba, K., Kato, E., Kumamoto, E. et al. Sustained potentiation of transmitter release by adrenaline and dibutyryl cyclic AMP in sympathetic ganglia. Nature 291, 654–656 (1981). https://doi.org/10.1038/291654a0
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DOI: https://doi.org/10.1038/291654a0
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