Abstract
Staphylococcus aureus produces a protein identified as protein A (SpA) with a molecular weight of 41,000 (ref. 1) which binds to the Fc region of many types of mammalian IgG2, activates complement3, blocks opsonins4 and is both chemotactic5 and mitogenic6,7. SpA has been used for various immunological purposes including removal of immune complexes8, arming effector cells with antibody9, distinguishing between antibody-dependent cell-mediated cytotoxicity (ADCC) and natural killing (NK)10, and exerting anti-tumour activity11. We have now demonstrated that SpA induces the production of γ interferon (IFN-γ) in nonadherent, T lymphocyte-depleted (E−), Fc receptor-bearing (FcR+) human peripheral blood lymphocytes. Our data also suggest that IFN-γ is a potent stimulator of both NK and ADCC activity.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Bjork, I., Peterson, B.-A. & Sjoquist, J. Eur. J. Biochem. 29, 579–584 (1972).
Kronvall, G. & Williams, R. C. J. Immun. 103, 828–833 (1969).
Kronvall, G. & Gewurz, H. Clin. exp. Immun. 7, 211–220 (1970).
Dossett, J. H., Kronvall, G., Williams, R. C. & Quie, P. G. J. Immun. 103, 1405–1410 (1969).
Harvey, R. L., Kronvall, G., Troup, G. M., Anderson, R. F. & Williams, R. C. Proc. Soc. exp. Biol. Med. 135, 453–456 (1970).
Forsgren, A., Svedjelund, A. & Wigzell, H. Eur. J. Immun. 6, 207–213 (1976).
Sakane, T. & Green, I. J. Immun. 120, 302–311 (1978).
Cowan, F. M., Klein, D. L., Armstrong, G. R. & Pearson, J. W. Biomedicine 30, 23–27 (1979).
Sulica, A., Lakey, M., Gherman, M., Ghetie, V. & Sjoquist, J. Scand. J. Immun. 5, 1191–1197(1976).
Kay, H. D., Gonnard, G. D., West, W. H. & Herverman, R. B. J. Immun. 118, 2058–2066 (1977).
Ray, P. K., Cooper, D. R., Bassett, J. G. & Mark, R. Fedn Proc. 38, 1089 (1979).
Langford, M. P., Georgiades, J. A., Stanton, G. J., Dianzani, F. & Johnson, H. M. Infect. Immun. 26, 36–41 (1979).
Catalona, W. J., Ratliff, T. L. & McCool, R. E. J. Immun. 122, 1009–1014 (1979).
Epstein, L. B. Tex. Rep. Biol. Med. 35, 42–56 (1977).
Wheelock, E. F. Science 169, 310–311 (1965).
Herberman, R. B., Ortaldo, J. R. & Bonnard, G. D. Nature 277, 221–223 (1979).
Vessella, R. L., Gormus, B. J., Lange, P. H. & Kaplan, M. E. Int. J. Cancer 21, 594–603 (1978).
Pape, G. R., Troye, M., Axelsson, B. & Perlman, P. J. Immun. 122, 2251–2260 (1979).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Catalona, W., Ratliff, T. & McCool, R. γ Interferon induced by S. aureus protein A augments natural killing and ADCC. Nature 291, 77–79 (1981). https://doi.org/10.1038/291077a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/291077a0
This article is cited by
-
Rapid αβ T-cell responses orchestrate innate immunity in response to Staphylococcal enterotoxin A
Mucosal Immunology (2013)
-
A Simple & Convenient Solid Phase Synthesis of Bacterial Origin Octapeptide Sequence, Glu-Asp-Gly-Asn-Lys-Pro-Gly-Lys-OH
International Journal of Peptide Research and Therapeutics (2010)
-
Enhanced macrophage antitumor effects of protein A in combination with IFN-γ
Archives of Pharmacal Research (1999)
-
Influence of alkali-treated cornsteep liquor containing medium on protein A production byStaphylococcus aureus
Folia Microbiologica (1998)
-
The effects of staphylococcal protein A on human lymphokine-activated killer cell induction
Cancer Immunology Immunotherapy (1991)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
