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Neural regulation of pancreatic hormone secretion by the C-terminal tetrapeptide of CCK

Nature volume 284, pages 33–38 (1980)Cite this article

Abstract

In pancreatic islets a peptide corresponding to the C-terminal tetrapeptide amide of cholecystokinin and gastrin, Trp-Met-Asp-Phe-NH2, is present in nerve terminals. This tetrapeptide amide is uniquely potent as a releaser of insulin and the other islet hormones, whereas larger cholecystokinins and gastrins as well as tetrapeptide analogues are considerably less potent. We suggest that neural release of the tetrapeptide amide is implicated in regulation of pancreatic hormone secretion.

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Author information

Authors and Affiliations

  1. Institute of Medical Biochemistry, University of Aarhus, Denmark

    J. F. Rehfeld, L.-I. Larsson, N. R. Goltermann & T. W. Schwartz

  2. Institute of Medical Physiology (C), University of Copenhagen, Denmark

    J. J. Holst

  3. Department of Surgery (C), Rigshospitalet, Copenhagen, Denmark

    S. L. Jensen

  4. Pharmaceutical Division, Imperial Chemical Industries Ltd, Alderley Park, Cheshire, UK

    J. S. Morley

Authors
  1. J. F. Rehfeld
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  2. L.-I. Larsson
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  3. N. R. Goltermann
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  4. T. W. Schwartz
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  5. J. J. Holst
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  6. S. L. Jensen
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  7. J. S. Morley
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Rehfeld, J., Larsson, LI., Goltermann, N. et al. Neural regulation of pancreatic hormone secretion by the C-terminal tetrapeptide of CCK. Nature 284, 33–38 (1980). https://doi.org/10.1038/284033a0

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