NK cell-sensitive T-cell subpopulation in thymus: inverse correlation to host NK activity

Abstract

NATURAL KILLER (NK) cells have been shown to have an important role in resistance to some tumours (see ref. 1 for review) and it has been suggested that these NK cells may represent a T cell and macrophage-independent surveillance mechanism2 similar in principle to the theory proposed by Burnet3 and Thomas4. Recent observations have led to the speculation that NK cells may also have a physiological role in vivo as NK cells were closely associated with the rejection of bone marrow grafts5,6. Although the target ‘antigens’ of NK cells have not yet been fully defined7, a wide range of malignant and non-transformed cells, including normal thymocytes17 and bone marrow cells8 are also sensitive to low levels of NK-mediated cytolysis. We provide evidence here to support the view that the NK cells may be involved in the control of normal T-cell subpopulations within the thymus.

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References

  1. 1

    Kiessling, R. & Wigzell, H. Transplant Proc. (in the press).

  2. 2

    Haller, O., Hansson, M., Kiessling, R. & Wigzell, H. Nature 270, 609–611 (1977).

  3. 3

    Burnet, F. M. Immunological Surveillance (Pergamon, London, 1970).

  4. 4

    Thomas, L. Cellular and Humoral Aspects of the Hypersensitive States (ed. Lawrence, H. S.) 529 (Cassell, London, 1959).

  5. 5

    Kiessling, R. et al. Eur. J. Immun. 7, 655–663 (1977).

  6. 6

    Trentin, J. et al. in Experimental Today (eds Baum, S. & Ledney, D.) 170–183 (Springer, New York, 1977).

  7. 7

    Roder, J. C., Rosén, A., Fenyö, E.-M. & Troy, F. A. Proc. natn. Acad. Sci. U.S.A. (in the press).

  8. 8

    Nunn, M. E., Herberman, R. B. & Holden, H. T. Int. J. Cancer 20, 381–387 (1977).

  9. 9

    Kiessling, R., Klein, E. & Wigzell, H. Eur. J. Immun. 5, 112–117 (1975).

  10. 10

    Trinchieri, G., Santoli, D. & Knowles, B. B. Nature 270, 611–613 (1977).

  11. 11

    Gidlund, M., Örn, A., Wigzell, H., Senik, A. & Gresser, I. Nature 273, 759–761 (1978).

  12. 12

    Gresser, I., Bourali, C., Lévy, J-P., Fontaine-Brouty-Boyé, D., & Thomas, M.-T., Proc. natn. Acad. Sci. U.S.A. 63, 51–57 (1969).

  13. 13

    Strander, H. et al. 377–381 (Fogarty Int. Center Proc. no. 28) (US Gov. Printing Office, Washington DC, 1977).

  14. 14

    Trinchieri, G. D., Santoli, R. R., Dee, R. R. & Knowles, B. B. J. exp. Med. 147, 1299–1313 (1978).

  15. 15

    Callewaert, D. M., Kaplan, J., Peterson, W. D. & Lightbody, J. J. Cell. Immun. 33, 11–19 (1977).

  16. 16

    Blomgren, H. & Andersson, B. Expl Cell Res. 57, 185–192 (1969).

  17. 17

    Ono, A. D., Amos, B. & Keren, H. S. Nature 266, 546 (1977).

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HANSSON, M., KIESSLING, R., ANDERSSON, B. et al. NK cell-sensitive T-cell subpopulation in thymus: inverse correlation to host NK activity. Nature 278, 174–176 (1979). https://doi.org/10.1038/278174a0

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