A novel bacteriophage defence mechanism: the anti-restriction protein

Abstract

Bacteriophage T3 and T7 protect their DNA from restriction by producing, as the earliest detectable phage functions, anti-restriction proteins. Although the two phage proteins differ in their Chromatographic and antigenic properties, they act by the same mechanism: the anti-restriction proteins inhibit E. coli K12 restriction endonuclease by direct interaction.

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Spoerel, N., Herrlich, P. & Bickle, T. A novel bacteriophage defence mechanism: the anti-restriction protein. Nature 278, 30–34 (1979). https://doi.org/10.1038/278030a0

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