Abstract
MANY samples hf ‘Sigma grade’ ATP from Sigma Chemical Co. reportedly contained an impurity which induces anomalous kinetics of (Na, K)-ATPase activity1–3. This impurity has recently been identified as vanadate4, and shown to inhibit (Na, K)–ATPase from kidney4 and red blood cells5. These findings have received considerable interest because of a possible physiological role of vanadate as an endogenous regulator of (Na, K)–ATPase activity3–5. We now report that vanadate is capable of producing positive inotropic effects in electrically driven papillary muscles isolated from cats.
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HACKBARTH, I., SCHMITZ, W., SCHOLZ, H. et al. Positive inotropism of vanadate in cat papillary muscle. Nature 275, 67 (1978). https://doi.org/10.1038/275067a0
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DOI: https://doi.org/10.1038/275067a0
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