Abstract
DURING a comparison of cytomegalovirus (CMV)-specific haemagglutinating and immunofluorescent antibody titres in human sera, 3 of 60 sera tested by indirect immunofluorescence gave homogenous nuclear staining in 100% of infected cells within 1 h after infection (p.i.). These antigens differ from EBNA-type antigens described recently by Geder1 in CMV-infected cells 3 h p.i. in that anticomplement immunofluorescence2 is not required for their detection. They differ from ‘early antigens’ (EA)3 in that they appear much sooner and are located uniquely in the nucleus. Finally, they differ from ‘late antigens’ (LA) for they appear in the absence of DNA synthesis. By analogy to antigens described for the pseudo-rabies system by Ben-Porat et al.4 and for herpes simplex virus type 1 by Beth et al.5, we term these antigens ‘immediate early antigens’ (IEA).
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References
Geder, L. J. gen. Virol. 32, 315–319 (1976).
Reedman, B. M. & Klein, G. Int. J. Cancer 2, 488–520 (1973).
The, T. H., Klein, G. & Langenhuysen, M. A. C. Clin. exp. Immun. 16, 1–12 (1974).
Ben-Porat, T., Kervina, M. & Kaplan, A. S. Virology 65, 355–362 (1975).
Beth, E., Giraldo, G. & Bernard, M. Biomedicine 25, 366–368 (1976).
Giraldo, G., Beth, E. & Haguenau, F. J. natn. Cancer Inst. 49, 1506–1526 (1972).
Guillon, J. C., Vincent, J. & Boche, R. Bull. Inst. Pasteur 73, 45–63 (1975).
Furukawa, T., Fioretti, A. & Plotkin, S. A. J. Virol. 11, 991–99 (1973).
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MICHELSON-FISKE, S., HORODNICEANU, F. & GUILLON, JC. Immediate early antigens in human cytomegalovirus infected cells. Nature 270, 615–617 (1977). https://doi.org/10.1038/270615a0
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DOI: https://doi.org/10.1038/270615a0
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