Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Type C RNA virus production and cell competence for normal differentiation in myeloid leukaemic cells

Nature volume 269, pages 173–175 (1977)Cite this article

Abstract

STUDIES with various species have shown that type C viral genomes can be integrated and vertically transmitted as chromosomal elements within the cellular genomes (for review see refs 1–6) and that nucleic acid sequences derived from these viruses can be detected in the DNA7–10 of normal cells (for review see ref. 11). It has been suggested that in addition to their role in tumour formation, type C RNA viruses may also have a role in normal cell differentiation2,3. We suggest here that one way in which these viruses may influence differentiation, is by modifying the competence of cells to be induced to differentiate by a normal regulator.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Gross, L. Oncogenic Viruses (Pergamon, New York, 1970).

    Google Scholar 

  2. Huebner, R. J. & Tadaro, G. J. Proc. natn. Acad. Sci. U.S.A. 64, 1087–1094 (1969).

    Article  ADS  CAS  Google Scholar 

  3. Temin, H. M. J. natn. Cancer Inst. 46, III–VII (1971).

    CAS  Google Scholar 

  4. Temin, H. M. & Baltimore, D. Adv. Virus Res. 17, 129–186 (1972).

    Article  CAS  PubMed  Google Scholar 

  5. Tooze, J. The Molecular Biology of Tumour Viruses (Cold Spring Harbor Laboratory, New York, 1973).

    Google Scholar 

  6. Gillespie, D., Saxinger, W. C. & Gallo, R. C. Prog. Nucleic Acid Res. molec. Biol. 15, 1–108 (1975).

    Article  CAS  Google Scholar 

  7. Gelb, L. D., Aaronson, S. A. & Martin, M. A. Science 172, 1353–1355 (1971).

    Article  ADS  CAS  PubMed  Google Scholar 

  8. Baluda, M. A. Proc. natn. Acad. Sci. U.S.A. 69, 576–580 (1972).

    Article  ADS  CAS  Google Scholar 

  9. Neiman, P. E. Virology 53, 196–203 (1973).

    Article  CAS  PubMed  Google Scholar 

  10. Gelb, L. D., Milstein, J. B., Martin, M. A. & Aaronson, S. A. Nature new Biol. 244, 76–79 (1973).

    Article  CAS  PubMed  Google Scholar 

  11. Aaronson, S. A. & Stephenson, J. R. Biochim. biophys. Acta 458, 323–354 (1976).

    CAS  PubMed  Google Scholar 

  12. Krantz, S. B. & Jacobson, L. O. Erythropotetin and the Regulation of Erythropoiesis (University of Chicago Press, Chicago, 1970).

    Google Scholar 

  13. Sachs, L. in Harvey Lectures 68, 1–35 (Academic, New York, 1974).

    Google Scholar 

  14. Landau, T. & Sachs, L. Proc. natn. Acad. Sci. U.S.A. 68, 2540–2544 (1971).

    Article  ADS  CAS  Google Scholar 

  15. Pluznik, D. H. & Sachs, L. J. cell. comp. Physiol. 66, 319–324 (1965).

    Article  CAS  Google Scholar 

  16. Pluznik, D. H. & Sachs, L. Expl Cell Res. 43, 553–563 (1966).

    Article  CAS  Google Scholar 

  17. Ichikawa, Y., Pluznik, D. H. & Sachs, L. Proc. natn. Acad. Sci. U.S.A. 56, 488–495 (1966).

    Article  ADS  CAS  Google Scholar 

  18. Bradley, T. R. & Metcalf, D. Aust. J. exp. Biol. med. Sci. 44, 287–299 (1966).

    Article  CAS  PubMed  Google Scholar 

  19. Fibach, E., Hayashi, M. & Sachs, L. Proc. natn. Acad. Sci. U.S.A. 70, 343–346 (1973).

    Article  ADS  CAS  Google Scholar 

  20. Lotem, J. & Sachs, L. Proc. natn. Acad. Sci. U.S.A. 71, 3507–3511 (1974).

    Article  ADS  CAS  Google Scholar 

  21. Lotem, J. & Sachs, L. J. Immun. 117, 580–586 (1976).

    CAS  PubMed  Google Scholar 

  22. Krystosek, A. & Sachs, L. Cell 9, 675–684 (1976).

    Article  CAS  PubMed  Google Scholar 

  23. Azumi, J. & Sachs, L. Proc. natn. Acad. Sci. U.S.A. 74, 253–257 (1977).

    Article  ADS  CAS  Google Scholar 

  24. Lotem, J. & Sachs, L. Int. J. Cancer 15, 731–740 (1975).

    Article  CAS  PubMed  Google Scholar 

  25. Metcalf, D. J. cell Physiol. 74, 323–332 (1969).

    Article  CAS  PubMed  Google Scholar 

  26. Austin, P. E., McCulloch, E. A. & Till, J. E. J. cell Physiol. 77, 121–134 (1971).

    Article  CAS  PubMed  Google Scholar 

  27. Ichikawa, Y. J. cell Physiol. 74, 223–234 (1969).

    Article  CAS  PubMed  Google Scholar 

  28. Lieber, M. M., Livingstone, P. M. & Todaro, G. F. Science 181, 443–444 (1974).

    Article  ADS  Google Scholar 

  29. Humphries, E. H. & Temin, H. M. J. Virol. 14, 531–546 (1974).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Greenberger, J. S. & Aaronson, S. A. J. Virol. 15, 64–70 (1975).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Fischinger, P. J., Tuttle-Fuller, N., Huper, G. & Bolognesi, D. P. J. Virol. 16 267–274 (1975).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Sherton, C. C., Evans, L. H., Polonoff, E. & Kabat, D. J. Virol. 19, 118–125 (1976).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Weissbach, A., Bolden, A., Muller, R., Hanafusa, H. & Hanafusa, T. J. Virol. 10, 321–327 (1972).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Baltimore, D. & Smoler, D. Proc. natn. Acad. Sci. U.S.A. 68, 1507–1511 (1970).

    Article  ADS  Google Scholar 

  35. Spiegelman, S. et al. Nature 228, 430–432 (1970).

    Article  ADS  CAS  PubMed  Google Scholar 

  36. Goodman, N. C. & Spiegelman, S. Proc. natn. Acad. Sci. U.S.A. 68, 2203–2206 (1971).

    Article  ADS  CAS  Google Scholar 

  37. Sarngadharan, M. G., Alloudeen, H. S. & Gallo, R. C. Meth. Cancer Res. 12, 3–47 (1976).

    CAS  Google Scholar 

  38. Liebermann, D., Voloch, Z., Aviv, H., Nudel, U. & Revel, M. Molec. Biol. Rep. 1, 447–451 (1974).

    Article  Google Scholar 

  39. Swetly, P. & Ostertag, W. Nature 251, 642–644 (1974).

    Article  ADS  CAS  PubMed  Google Scholar 

  40. Metz, D. H. Cell 6, 429–439 (1975).

    Article  CAS  Google Scholar 

  41. Hilgers, J., Nowinski, R. C., Geering, G. & Hardy, W. Cancer Res. 32, 98–106 (1972).

    CAS  PubMed  Google Scholar 

  42. Haas, M. J. natn. Cancer Inst. 58, 251–257 (1977).

    Article  CAS  Google Scholar 

  43. Mak, T. W., Manaster, J., Howatson, A. F., McCulloch, E. A. & Till, J. E. Proc. natn. Acad. Sci. U.S.A. 71, 4336–4340 (1974).

    Article  ADS  CAS  Google Scholar 

  44. Gallagher, R. E., Salahuddin, S. Z., Hall, W. T., McCredie, K. B. & Gallo, R. C. Proc. natn. Acad. Sci. U.S.A. 72, 4137–4141 (1975).

    Article  ADS  CAS  Google Scholar 

  45. Greenberger, J. S., Aaronson, S. A., Rosenthal, D. S. & Moloney, W. C. Nature 257, 143–144 (1975).

    Article  ADS  CAS  PubMed  Google Scholar 

  46. Friend, C., Scher, W., Holland, J. G. & Sato, T. Proc. natn. Acad. Sci. U.S.A. 68, 378–382 (1971).

    Article  ADS  CAS  Google Scholar 

  47. Reuben, R. C., Wife, R. L., Breslow, R., Rifkind, R. & Marks, P. A. Proc. natn. Acad. Sci. U.S.A. 73, 862–866 (1976).

    Article  ADS  CAS  Google Scholar 

  48. Kluge, N., Gaedicke, G., Steinheider, G., Dube, S. & Ostertag, W. Expl Cell Res. 88, 257–262 (1974).

    Article  CAS  Google Scholar 

  49. Lotem, J., Vlodavsky, I. & Sachs, L. Expl Cell Res. 101, 323–330 (1976).

    Article  CAS  Google Scholar 

  50. Todaro, G. J., DeLarco, J. E. & Cohen, S. Nature 264, 26–31 (1975).

    Article  ADS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Genetics, Weizmann Institute of Science, Rehovot, Israel

    DAN LIEBERMANN & LEO SACHS

Authors
  1. DAN LIEBERMANN
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. LEO SACHS
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

LIEBERMANN, D., SACHS, L. Type C RNA virus production and cell competence for normal differentiation in myeloid leukaemic cells. Nature 269, 173–175 (1977). https://doi.org/10.1038/269173a0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/269173a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing