Type C RNA virus production and cell competence for normal differentiation in myeloid leukaemic cells

Abstract

STUDIES with various species have shown that type C viral genomes can be integrated and vertically transmitted as chromosomal elements within the cellular genomes (for review see refs 1–6) and that nucleic acid sequences derived from these viruses can be detected in the DNA7–10 of normal cells (for review see ref. 11). It has been suggested that in addition to their role in tumour formation, type C RNA viruses may also have a role in normal cell differentiation2,3. We suggest here that one way in which these viruses may influence differentiation, is by modifying the competence of cells to be induced to differentiate by a normal regulator.

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LIEBERMANN, D., SACHS, L. Type C RNA virus production and cell competence for normal differentiation in myeloid leukaemic cells. Nature 269, 173–175 (1977). https://doi.org/10.1038/269173a0

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