Abstract
AN in vivo voltammetry technique has been developed which enables direct and continuous measurement to be made of the release of neurotransmitter metabolites in cerebrospinal fluid (CSF) after electrical stimulation or pharmacological manipulations of neural pathways. The measurement is very simple in principle. A potential is applied to a micro carbon electrode stereotaxically placed in a lateral ventricle. One then measures the minute current which results from the oxidation or reduction of small molecular weight constituents near the sensor electrode. The potential at which the electrolysis occurs serves as a qualitative indication of the constituent being monitored and the current itself is directly proportional to the concentration of this component in CSF.
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WIGHTMAN, R., STROPE, E., PLOTSKY, P. et al. Monitoring of transmitter metabolites by voltammetry in cerebrospinal fluid following neural pathway stimulation. Nature 262, 145–146 (1976). https://doi.org/10.1038/262145a0
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DOI: https://doi.org/10.1038/262145a0
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