Abstract
IT is well established that distinct changes in the antigenic phenotype of the cell surface accompany viral transformation. The ‘new’ determinants may be viral, oncofoetal (or ‘phase’ specific) or tumour specific1–3. The identification of neoantigens, and particularly putative tumour specific antigens, on human neoplasms opens up possibilities of early and precise diagnosis, patient monitoring and immunotherapy. It may also eventually provide information relevant to the aetiology of the disease. We report here the demonstration of a cell surface antigen present on leukaemic cells from patients with acute lymphoblastic leukaemia (ALL).
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BROWN, G., HOGG, N. & GREAVES, M. Candidate leukaemia-specific antigen in man. Nature 258, 454–456 (1975). https://doi.org/10.1038/258454a0
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DOI: https://doi.org/10.1038/258454a0
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