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Receptor-mediated inactivation of early B lymphocytes

Naturevolume 257pages149151 (1975) | Download Citation



THE interaction of surface immunoglobulin (sIg), the antigen receptor of B lymphocytes, with ligands—whether antigen or anti-Ig antibodies—initiates a series of surface and cytoplasmic events which, depending on the nature of the ligand and the presence or absence of cooperative signals from other cells, has various outcomes (reviewed in ref. 1). Immediately on the binding of a polyvalent ligand to sIg, the complexes redistribute on the cell surface, a contractile event occurs, the complexes are endocytosed and shed from the membrane and eventually new receptors appear on the cell surface1. This in vitro cycle, in the absence of cooperative interactions, does not lead to B cell differentiation into secreting plasma cells, whereas it does so when induced in the proper conditions involving helper cells1,2.

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  1. Department of Pathology, Harvard Medical School, Boston, Massachusetts, 02115

    •  & EMIL R. UNANUE


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