Abstract
THE interaction of surface immunoglobulin (sIg), the antigen receptor of B lymphocytes, with ligands—whether antigen or anti-Ig antibodies—initiates a series of surface and cytoplasmic events which, depending on the nature of the ligand and the presence or absence of cooperative signals from other cells, has various outcomes (reviewed in ref. 1). Immediately on the binding of a polyvalent ligand to sIg, the complexes redistribute on the cell surface, a contractile event occurs, the complexes are endocytosed and shed from the membrane and eventually new receptors appear on the cell surface1. This in vitro cycle, in the absence of cooperative interactions, does not lead to B cell differentiation into secreting plasma cells, whereas it does so when induced in the proper conditions involving helper cells1,2.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Unanue, E. R., Am. J. Path., 77, 1–20 (1974).
Kishimoto, T., and Ishizaka, K., J. Immun., 114, 585–591 (1975).
Gelfand, M. C., Elfenbein, G. J., and Paul, W. E., J. exp. Med., 139, 1125–1141 (1974).
Sidman, C. L., and Unanue, E. R., J. Immun., 114, 1730–1735 (1975).
Shreffler, D. C., and David, C. S., Adv. Immun., 20, 125–195 (1975).
Unanue, E. R., Dorf, M. E., David, C. S., and Benacerraf, B., Proc. natn. Acad. Sci.U.S.A., 71, 5014–5016 (1974).
Ault, K. A., Unanue, E. R., Katz, D. H., and Benacerraf, B., Proc. natn. Acad. Sci. U.S.A., 71, 3111–3114 (1974).
Strayer, D. S., Cosenza, H., Lee, W. M. F., Rowley, D. A., and Köhler, H., Science, 186, 640–643 (1974).
Köhler, H., Kaplan, D. R., and Strayer, D. S., Science, 186, 643–644 (1974).
Lawton, A. R., Asofsky, R., Hylton, M., B., and Cooper, M. D., J. exp. Med., 135, 277–297 (1972).
Mosier, D. E., and Johnson, B. M., J. exp. Med., 141, 216–226 (1975).
Ryser, J. E., and Vassali, P., J. Immun., 113, 719–728 (1974).
Osmond, D. G., J. reticuloendothel. Soc., 17, 99–114 (1975).
Nossal, G. J. V., and Pike, B., J. exp. Med., 141, 904–917 (1975).
Mishell, R. I., and Dutton, R. W., J. exp. Med., 126, 423–442 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SIDMAN, C., UNANUE, E. Receptor-mediated inactivation of early B lymphocytes. Nature 257, 149–151 (1975). https://doi.org/10.1038/257149a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/257149a0
This article is cited by
-
The roles of c‐rel and interleukin‐2 in tolerance: a molecular explanation of self–nonself discrimination
Immunology & Cell Biology (2011)
-
Immunological tolerance 50 years after the Burnet Nobel Prize
Immunology & Cell Biology (2011)
-
Self-reactive B cells in nonautoimmune and autoimmune mice
Immunologic Research (1998)
-
The B-cell antigen receptor of the five immunoglobulin classes
Nature (1991)
-
Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens
Nature (1991)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
