Abstract
FOREIGN bodies, including microorganisms, ingested by cultured mouse peritoneal macrophages become enclosed within phagosomes. Usually lysosome granules promptly assemble close to the phagosomes and fuse with their membranes, exposing the ingested objects to digestive enzymes1–3. Much of the kinetics of phagosome–lysosome fusion and degranulation in leukocytes was described by Robineaux, Hirsch, Cohn and their co-workers4–7, but the mechanisms and factors controlling them are only now beginning to emerge8,9.
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HART, P., YOUNG, M. Interference with normal phagosome-lysosome fusion in macrophages, using ingested yeast cells and suramin. Nature 256, 47–49 (1975). https://doi.org/10.1038/256047a0
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DOI: https://doi.org/10.1038/256047a0
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