Abstract
A PROTEIN kinase, the genetic information for which is phage-coded, is induced after infection of Escherichia coli with either phage T7 or T3 (ref. 1). The protein kinase is important in the regulation of gene expression in that it inhibits the initiation of transcription by E. coli RNA polymerase and in that it restricts host-dependent transcription of the T7 genome to the early region2. T7 protein kinase phosphorylates the β′ subunit of E. coli RNA polymerase (this action provides an explanation for the effects on transcription) and other E. coli proteins1,2.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Rahmsdorf, H. J., et al., Proc. natn. Acad. Sci. U.S.A., 71, 586 (1974).
Ponta, H., et al., Molec. gen. Genet., 134, 281 (1974).
Rubenstein, I., Virology, 36, 356 (1968).
Parkinson, J. S., and Huskey, R. J., J. molec. Biol., 56, 369 (1971).
Studier, F. W., Science, 176, 367 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HIRSCH-KAUFFMANN, M., HERRLICH, P., PONTA, H. et al. Helper function of T7 protein kinase in virus propagation. Nature 255, 508–510 (1975). https://doi.org/10.1038/255508a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/255508a0
This article is cited by
-
Phage Paride can kill dormant, antibiotic-tolerant cells of Pseudomonas aeruginosa by direct lytic replication
Nature Communications (2024)
-
Mechanism of Ribonuclease III Catalytic Regulation by Serine Phosphorylation
Scientific Reports (2016)
-
Gene expression in mitochondria and bacteria
Molecular and Cellular Biochemistry (1977)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.