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Human lymphocytes recognise mouse alloantigens

Nature volume 254, pages 607–609 (1975)Cite this article

Abstract

H-2 LD antigens1 of the mouse major histocompatibility complex and the lymphocyte-activating determinants of the Mls (ref. 2) locus induce vigorous lymphocyte proliferation and enhance generation of cytotoxic effector cells in allogeneic combinations (ref. 3 and D. J. Schendel, and F. H. Bach, unpublished). These antigens do not serve well as targets for cell-mediated lympholysis (CML)—a function which in the mouse is performed by the classical H-2 determinants, the SD antigens4,5. A similar differential function of LD and SD antigens is found in human allograft reactions in vitro6.

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Authors and Affiliations

  1. Immunobiology Research Center and Departments of Medical Genetics and Surgery, The University of Wisconsin, Madison, Wisconsin, 53706

    KIRSTEN FISCHER LINDAHL & FRITZ H. BACH

Authors
  1. KIRSTEN FISCHER LINDAHL
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  2. FRITZ H. BACH
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LINDAHL, K., BACH, F. Human lymphocytes recognise mouse alloantigens. Nature 254, 607–609 (1975). https://doi.org/10.1038/254607a0

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