Letter | Published:

Sudden appearance of IgG plaque-forming cells

Naturevolume 254pages6162 (1975) | Download Citation



EXPERIMENTS described here show that a large number of indirect, presumably IgG, plaque-forming cells (PFC) appear within a few hours during the initial stages of the IgG response of BALB/c mice to sheep red cells. When washed spleen cells are placed in vitro over the appropriate period indirect PFC develop as well as in vivo, but a few hours earlier.

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  1. 1

    Cunningham, A. J., and Szenebrg, A., Immunology, 14, 599–601 (1968).

  2. 2

    Nossal, G. J. V., Lewis, H., and Warner, N. L., Cellular Immun., 2, 13–40 (1971).

  3. 3

    Wortis, H. H., Taylor, R. B., and Dresser, D. W., Immunology, 11, 603–613 (1963).

  4. 4

    Zaalberg, O. B., Van der Meul, V. A., and Rossi, G., Eur. J. Immun., 3, 698–703 (1973).

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  1. Department of Experimental Pathology, St. Mary's Hospital Medical School, London, W2 1PG, UK

    • I. E. ADDISON


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