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Crystal structure of proflavine, a DNA binding agent

Nature volume 253, pages 284–285 (1975)Cite this article

Abstract

THE subject of DNA–small molecule binding has received much attention in recent years. Particular emphasis has been placed on aminoacridine binding1, and many studies have employed proflavine (Fig. 1) as perhaps the classical interacting agent of these series of drugs. The DNA-binding properties of proflavine cause it to act as a frameshift mutagen, and this ability has been extensively utilised in molecular genetics2.

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Authors and Affiliations

  1. Department of Biophysics, King's College, 26–29 Drury Lane, London, WC2B 5RL, UK

    S. NEIDLE & T. A. JONES

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  1. S. NEIDLE
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  2. T. A. JONES
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NEIDLE, S., JONES, T. Crystal structure of proflavine, a DNA binding agent. Nature 253, 284–285 (1975). https://doi.org/10.1038/253284a0

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