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Cell-mediated immunity to Epstein–Barr virus and a blocking factor in patients with infectious mononucleosis

Nature volume 252, pages 608–610 (1974)Cite this article

Abstract

ALTHOUGH the humoral immune response to Epstein–Barr virus (EBV) in infectious mononucleosis (IM) has been studied extensively1,2, little is known about cell-mediated immunity (CMI) to EBV in the disease. We describe here the status of CMI to EBV, and the presence of a blocking factor which can abrogate leukocyte migration inhibition, in patients with IM.

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Authors and Affiliations

  1. Department of Microbiology, University of Western Australia, Perth Medical Centre,

    PATRICK K. LAI

  2. Department of Virology, State Health Laboratory Services, Perth Medical Centre,

    EWART M. MACKAY-SCOLLAY

  3. Division of Haematology, Hollywood Repatriation Hospital, Western Australia, 6009

    PETER J. FIMMEL

  4. Department of Microbiology, University of Western Australia, Perth Medical Centre, Western Australia, 6008

    MICHAEL P. ALPERS & DAVID KEAST

Authors
  1. PATRICK K. LAI
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  2. EWART M. MACKAY-SCOLLAY
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  3. PETER J. FIMMEL
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  4. MICHAEL P. ALPERS
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  5. DAVID KEAST
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LAI, P., MACKAY-SCOLLAY, E., FIMMEL, P. et al. Cell-mediated immunity to Epstein–Barr virus and a blocking factor in patients with infectious mononucleosis. Nature 252, 608–610 (1974). https://doi.org/10.1038/252608a0

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