Abstract
1,25-DIHYDROXYCHOLECALCIFEROL (1,25 DHCC) is the most active metabolite of vitamin D31–4, and its production by the kidney in vivo varies with the calcium and vitamin D content of the diet5. In spite of several theories, the mechanisms by which dietary changes cause alterations in 1,25 DHCC production are not completely understood. Hormonal6–8 and ionic9–11 messengers have been suggested, and both may have a role.
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References
Kodicek, E., Lawson, D. E. M., and Wilson, P. W., Nature, 228, 763–764 (1970).
Haussler, M. R., Boyce, D. S., Littledike, E. T., and Rasmussen, H., Proc. natn. Acad. Sci. U.S.A., 68, 177–181 (1971).
Myrtle, J. F., and Norman, A. W., Science, 171, 79–82 (1971).
Omdahl, J., Holick, M., Suda, T., Tanaka, Y., and DeLuca, H. F., Biochemistry, 10, 2935–2940 (1971).
Boyle, I. T., Gray, R. W., and DeLuca, H. F., Proc. natn. Acad. Sci. U.S.A., 68, 2131–2134 (1971).
Garabedian, M., Holick, M. F., DeLuca, H. F., and Boyle, I. T., Proc. natn. Acad. Sci. U.S.A., 69, 1673–1676 (1972).
Rasmussen, H., Wong, M., Bikle, D., and Goodman, D. B. P., J. clin. Invest., 51, 2502–2504 (1972).
Fraser, D. R., and Kodicek, E., Nature new Biol., 241, 163–166 (1973).
Colston, K. W., Evans, I. M. A., Galante, L., MacIntyre, I., and Moss, D. W., Biochem. J., 134, 817–820 (1973).
Larkins, R. G., MacAuley, S. J., Rapoport, A., Martin, T. J., Tulloch, B. R., Byfield, P. G. H., Matthews, E. W., and MacIntyre, I., Clin. Sci. molec. Med., 46, 569–582 (1974).
Favus, M. J., Walling, M. W., and Kimberg, D. V., J. clin. Invest., 53, 1139–1148 (1974).
Reich, E., and Goldberg, I. H., Progr. nucleic Acid Res. molec. Biol., 3, 183–231 (1964).
Beard, N. S., Armentrout, S. A., and Weisberger, A. S., Pharmacol. Rev., 21, 213–245 (1969).
Corradino, R. A., Nature, 243, 41–43 (1973).
Emtage, J. S., Lawson, D. E. M., and Kodicek, E., Nature, 246, 100–101 (1973).
Puschett, J. B., Fernandez, P. C., Boyle, I. T., Gray, R. W., Omdahl, J. L., and DeLuca, H. F., Proc. Soc. exp. Biol. Med., 141, 379–384 (1972).
Taylor, A. N., and Wasserman, R. H., Am. J. Physiol., 223, 110–114 (1972).
Reed, P. W., and Lardy, H. A., J. biol. Chem., 247, 6970–6977 (1972).
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LARKINS, R., MACAULEY, S. & MACINTYRE, I. Feedback control of vitamin D metabolism by a nuclear action of 1,25-dihydroxycholecalciferol on the kidney. Nature 252, 412–414 (1974). https://doi.org/10.1038/252412a0
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DOI: https://doi.org/10.1038/252412a0
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