Abstract
Temperature sensitivity of growth and transformation by certain early Rous sarcoma virus mutants correlates with thermolability of their virion-associated DNA polymerase. The enzyme is therefore encoded by viral RNA and is required for provirus synthesis.
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References
Wyke, J. A., Virology, 52, 587 (1973).
Linial, M., and Mason, W. S., Virology, 53, 258 (1973).
Vogt, P. K., Weiss, R. A., and Hanafusa, H., J. Virol, 13, 551 (1974).
Temin, H. M., and Baltimore, D., in Advances in virus research, 17, 129 (Academic Press, New York, 1972).
Baltimore, D., and Smoler, D. F., Proc. natn. Acad. Sci. U.S.A., 68, 1507 (1971).
Verma, I. M., and Baltimore, D., in Methods in enzymology (edit. by Grossman, L., and Moldave, K.), 29, 125 (Academic Press, New York, 1973).
Verma, I. M., Meuth, N. L., Fan, H., and Baltimore, D., J. Virol., 13, 1075 (1974).
Grandgenett, D. P., Gerard, G. F., and Green, M., Proc. natn. Acad. Sci. U.S.A., 70, 230 (1973).
Kacian, D. L., Watson, K. F., Burny, A., and Spiegelman, S., Biochim. biophys. Acta, 246, 365 (1971).
Faras, A. J., Taylor, J. M., McDonald, J. P., Levinson, W. E., and Bishop, J. M., Biochemistry, 11, 2334 (1972).
Loeb, L. A., J. biol. Chem., 244, 1672 (1969).
Leis, J., Berkower, I., and Hurwitz, J., in DNA synthesis in vitro (edit. by Wells, R. D., and Inman, R. B.), 287 (University Park Press, Baltimore, 1973).
Kawai, S., and Hanafusa, H., Virology, 49, 37 (1972).
Vogt, P. K., Virology, 46, 947 (1971).
The molecular biology of tumour viruses (edit. by Tooze, J.) Ch. 11 (Cold Spring Harbor Laboratory, Cold Spring Harbor, 1973).
Ross, J., Scolnick, E. M., Todaro, G., and Aaronson, S. A., Nature new Biol., 231, 163 (1972).
Baltimore, D., McCaffrey, R., and Smoler, D. F., in Virus research (edit. by Fox, C. F., and Robinson, W. S.), 51 (Academic Press, New York, 1973).
Hanafusa, H., Baltimore, D., Smoler, D. F., Watson, K. F., Yaniv, A., and Spiegelman, S., Science, 177, 1188 (1972).
Peebles, P. T., Haapala, D. K., and Gazdar, A. F., J. gen. Virol., 9, 488 (1972).
May, J. T., Somers, K. D., and Kit, S., J. gen. Virol., 16, 223 (1972).
Somers, K. D., May, J. T., Kit, S., McCormick, K. J., Hatch, G. G., Stenback, W. A., and Trentin, J. J., Intervirology, 1, 11 (1973).
Bishop, J. M., Quintrell, N., Medeiros, E., and Varmus, H. E., Cancer (in the press).
Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem., 193, 265 (1951).
Baltimore, D., Huang, A. S., and Stampfer, M., Proc. natn. Acad. Sci. U.S.A., 66, 572 (1970).
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Verma, I., Mason, W., Drost, S. et al. DNA polymerase activity from two temperature-sensitive mutants of Rous sarcoma virus is thermolabile. Nature 251, 27–31 (1974). https://doi.org/10.1038/251027a0
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DOI: https://doi.org/10.1038/251027a0
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