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Transepithelial potential difference in toad urinary bladder is not due to ionic diffusion

Nature volume 250, pages 495–496 (1974)Cite this article

Abstract

KOEFOED-JOHNSEN and Ussing proposed1 that the transepithelial potential difference (PD) in frog skin was due to the sum of two diffusion potentials, one at the outside border due to sodium, and one at the inside due to potassium. Others have shown somewhat similar results in toad urinary bladder2,3. Although there is evidence to support the notion that such a mechanism cannot account for the entire PD4–6, the hypothesis is still favoured by many investigators.

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References

  1. Koefoed-Johnson, V., and Ussing, H. H., Acta physiol. scand., 42, 298–308 (1958).

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  2. Gatzy, J. T., and Clarkson, T. W., J. gen. Physiol., 48, 647–671 (1965).

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  3. Leb, D. E., Hoshiko, T., and Lindley, B. D., J. gen. Physiol., 48, 527–540 (1965).

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Authors and Affiliations

  1. Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, 27514

    ARTHUR L. FINN

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  1. ARTHUR L. FINN
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FINN, A. Transepithelial potential difference in toad urinary bladder is not due to ionic diffusion. Nature 250, 495–496 (1974). https://doi.org/10.1038/250495a0

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