Abstract
THE theory of allogeneic stimulation1 postulates that transplantation antigens, such as H-2 in the mouse or H-LA in man, are not strong immunogens for allogeneic animals, but are rendered highly immunogenic when presented to the immune system in conjunction with an allogeneic stimulus. The capacity to provide an allogeneic stimulus is the property of metabolically active2–4 immunocompetent cells1, and it has been suggested that allogeneic stimulation requires the transfer of some cytoplasmic component from the stimulating to the responsive cell1. According to this hypothesis, any treatment that inactivates the metabolic activity of lymphoid cells will reduce their immunogenicity for other members of the same species.
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LAFFERTY, K., MISKO, I. & COOLEY, M. Allogeneic stimulation modulates the in vitro response of T cells to transplantation antigen. Nature 249, 275–276 (1974). https://doi.org/10.1038/249275a0
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DOI: https://doi.org/10.1038/249275a0
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