Abstract
IN an attempt to elucidate the functions of the nervous system using behavioural mutants of Drosophila melanogaster, several sex-linked temperature-sensitive paralysis mutants have been isolated1,2. These mutants are reversibly paralysed at 29° C while remaining normal at 22° C. The author set out to determine the molecular basis for the paralysis in one allelic series of these mutants, shibire temperature-sensitive (shits)2.
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References
Grigliatti, T. A., Williamson, R., and Suzuki, D. T., Genetics, 64, S27 (1970).
Grigliatti, T. A., Hall, L., Rosenbluth, R., and Suzuki, D. T., Molec. gen. Genet., 120, 107 (1973).
Narahashi, T., Moore, J., and Scott, W. R., J. gen. Physiol., 47, 965 (1964).
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KELLY, L. Temperature-sensitive mutations affecting the regenerative sodium channel in Drosophila melanogaster. Nature 248, 166–168 (1974). https://doi.org/10.1038/248166a0
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DOI: https://doi.org/10.1038/248166a0
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