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Mechanism of denaturation of haemoglobin by alkali

Nature volume 247, pages 341–344 (1974)Cite this article

Abstract

Denaturation by alkali is activated by the ionisation of buried, weakly acidic side chains. Species variations are largely accounted for by replacements of one buried tyrosine and two cysteines.

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Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Rd, Cambridge

    M. F. Perutz

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  1. M. F. Perutz
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Perutz, M. Mechanism of denaturation of haemoglobin by alkali. Nature 247, 341–344 (1974). https://doi.org/10.1038/247341a0

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