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p-Fluoropheiiylalanine and ‘Division-related Proteins’

Naturevolume 247pages281283 (1974) | Download Citation



CELLS approaching mitosis after completion of DNA synthesis are believed to synthesise certain RNA messages and to translate these in order that proteins essential for mitosis become available1–6. The synthesis during G2 of ‘division-related proteins’ is by no means proven, however, and there is distinctly contradictory evidence in the case of HeLa cells7. The time spent in G2 varies considerably between cell types and the synthesis of proteins involved in the mitotic process might be sufficiently complete by mid S phase in some cell lines while it is only accomplished by late G2 in others. If we assume, however, that proteins specifically related to division are made in G2, then it is of interest to know the latest time that they can be made before division, and what they do.

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  1. Department of Pathology, University Medical Buildings, Foresterhill, Aberdeen, AB9 2ZD

    • D. N. WHEATLEY


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