Abstract
THE transport of RNA from the cell nucleus to the cytoplasm is likely to be a composite process, the details of which are far from clear. There is a large discrepancy in molecular size between polysomal mRNA and its tentative precursor, the high molecular-weight, non-ribosomal, nuclear RNA (H RNA)1. Also, a considerable part of H RNA does not enter the cytoplasm, but is degraded to acid-soluble products within the nucleus1. To explain these findings it has been suggested that H RNA is cleaved to smaller molecules, among which mRNA sequences are selected for transfer to the cytoplasm2. In the study of such transport phenomena it would be advantageous to follow a specific RNA from its site of synthesis in the chromosomes to its functional locality in the cytoplasm. This possibility may be offered in the study of RNA from the giant puff Balbiani ring 2 (BR 2) in the polytene chromosomes of Chironomus tentans salivary glands.
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LAMBERT, B. Tracing of RNA from a Puff in the Polytene Chromosomes to the Cytoplasm in Chironomus tentans Salivary Gland Cells. Nature 242, 51–53 (1973). https://doi.org/10.1038/242051a0
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DOI: https://doi.org/10.1038/242051a0
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