Letter | Published:

Oestrogen Receptor Binding is not restricted to Target Nuclei

Abstract

WHEN oestrogen molecules enter a target cell they are bound by specific receptors in the cytoplasm which then enter the nucleus carrying the hormone1. In the nucleus the hormone-receptor complexes bind to acceptor sites, where they presumably initiate the sequence of events comprising the hormone response.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Jensen, E. V., Numata, M., Brecher, P. I., and DeSombre, E. R., in The Biochemistry of Steroid Hormone Action, Biochem. Soc. Symposium No. 32 (edit. by Smellie, R. M. S.), 133 (Academic Press, London, 1971).

  2. 2

    Jensen, E. V., and Jacobson, H. I., Recent Progr Hormone Res., 18, 387 (1962).

  3. 3

    Toft, D., and Gorski, J., Proc. US Nat. Acad. Sci., 55, 1574 (1966).

  4. 4

    McGuire, W. L., and Julian, J. A., Cancer Res, 31, 1440 (1971).

  5. 5

    Jensen, E. V., Numata, M., Smith, S., Suzuki, T., Brecher, P. L., and DeSombre, E. R., in Communication in Development, Twenty-eighth Symposium, Society for Developmental Biology (edit. by Lang, A.), 151 (Academic Press, New York, 1969).

  6. 6

    Musliner, T. A., Chader, G. J., and Villee, C. A., Biochemistry, 9, 4448 (1970).

  7. 7

    Steggles, A. W., Spelsberg, T. C., Glasser, S. R., and O'Malley, B. W., Proc. US Nat. Acad. Sci., 68, 1479 (1971).

  8. 8

    Gschwendt, M., and Hamilton, T. H., Biochem. J., 128, 611 (1972).

  9. 9

    Clark, J. H., and Gorski, J., Biochim. Biophys. Acta, 192, 508 (1969).

  10. 10

    McGuire, W. L., Julian, J. A., and Chamness, G. C., Endocrinology, 89, 969 (1971).

  11. 11

    McGuire, W. L., Huff, K., Jennings, A., and Chamness, G. C., Science, 175, 335 (1972).

  12. 12

    McGuire, W. L., Huff, K., and Chamness, G. C., Biochemistry, 71, 4562 (1972).

  13. 13

    Davidson, J. N., The Biochemistry of the Nucleic Acids (sixth ed.), 325 (Methuen, London, 1969).

  14. 14

    Chamness, G. C., and McGuire, W. L., Biochemistry, 11, 2466 (1972).

  15. 15

    Brecher, P. I., Numata, M., DeSombre, E. R., and Jensen, E. V., Fed. Proc., 29, 249 (1970).

  16. 16

    Mohla, S., DeSombre, E. R., and Jensen, E. V., Biochem. Biophys. Res. Commun., 46, 661 (1972).

  17. 17

    Spelsberg, T. C., Steggles, A. W., and O'Malley, B. W., J. Biol Chem., 246, 4188 (1971).

  18. 18

    O'Malley, B. W., Spelsberg, T. C., Schrader, W. T., Chytil, F., and Steggles, A. W., Nature, 235, 141 (1972).

  19. 19

    Fang, S., and Liao, S., J. Biol Chem., 246, 16 (1971).

  20. 20

    Mainwaring, W. I. P., and Peterken, B. M., Biochem. J., 125, 285 (1971).

  21. 21

    Spelsberg, T. C., and Hnilica, L. S., Biochim. Biophys. Acta, 228, 202 (1971).

  22. 22

    Steggles, A. W., Spelsberg, T. C., and O'Malley, B. W., Biochem. Biophys. Res. Commun., 43, 20 (1971).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.