Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

A Possible Role for Histone in the Synthesis of DNA

Nature volume 240, pages 449–453 (1972)Cite this article

Abstract

When protein synthesis is inhibited, DNA synthesis continues normally but with a slower rate of chain elongation. Dr H. Weintraub speculates that the histones are the DNA chain elongation proteins.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Weintraub, H., and Holtzer, H., J. Mol. Biol., 65, 13 (1972).

    Article  Google Scholar 

  2. Weintraub, H., Campbell, G., and Holtzer, H., J. Mol. Biol. (in the press).

  3. Spalding, J., Kajiwara, K., and Mueller, G. C., Proc. US Nat. Acad. Sci., 56, 1535 (1966).

    Article  ADS  CAS  Google Scholar 

  4. Malpoix, P., Zampetti, F., and Fievez, M., Biochim. Biophys. Acta, 182, 214 (1969).

    Article  CAS  Google Scholar 

  5. Freedman, M. L., Honig, G. R., and Rabinovitz, M., Exp. Cell Res., 44, 263 (1966).

    Article  CAS  Google Scholar 

  6. Borun, T. W., Scharff, M. D., and Robbins, E., Proc. US Nat. Acad. Sci., 58, 1977 (1967).

    Article  ADS  CAS  Google Scholar 

  7. Mueller, G. C., and Kajiwara, K., Biochim. Biophys. Acta, 119, 557 (1966).

    Article  CAS  Google Scholar 

  8. Sadgopal, S., and Bonner, J., Biochim. Biophys. Acta, 186, 349 (1969).

    Article  CAS  Google Scholar 

  9. Friedman, D. L., and Mueller, G. C., Biochim. Biophys. Acta, 174, 253 (1969).

    Article  CAS  Google Scholar 

  10. Pearson, G. D., and Hanawalt, P. C., J. Mol. Biol., 62, 65 (1971).

    Article  CAS  Google Scholar 

  11. Fakan, S., Turner, G., Pagana, J., and Hancock, R., Proc. US Nat. Acad. Sci., 69, 2300 (1972).

    Article  ADS  CAS  Google Scholar 

  12. Kuo, C. H., and August, J. T., Nature, 237, 105 (1972).

    Article  CAS  Google Scholar 

  13. Schachtele, C. F., Anderson, D. L., and Rogers, P., J. Mol. Biol., 49, 255 (1970).

    Article  CAS  Google Scholar 

  14. Iwaya, M., and Denhardt, D. T., J. Mol. Biol., 57, 159 (1971).

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. HAROLD WEINTRAUB

    Present address: MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, England

Authors and Affiliations

  1. Department of Anatomy, University of Pennsylvania, Philadelphia, Pennsylvania, 19104

    HAROLD WEINTRAUB

Authors
  1. HAROLD WEINTRAUB
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

WEINTRAUB, H. A Possible Role for Histone in the Synthesis of DNA. Nature 240, 449–453 (1972). https://doi.org/10.1038/240449a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/240449a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing