Abstract
THE gas phase of cigarette smoke (Cambridge and activated charcoal filter) has been shown to have a detrimental effect on several performance tests with rats, including swimming endurance1 and avoidance response2. The gas-vapour phase (Cambridge filter alone) had a significantly less toxic effect in these tests. These results were attributed to differences in respiration, in which breathing was apparently more inhibited by the irritants3 in the gas-vapour phase, resulting in a larger intake of toxic CO4 when the gas phase was presented alone. The purpose of this study was to test this hypothesis by measuring the respiratory response to these filter conditions, and to correlate this with %COHb measured immediately after “smoking”. As an index of respiratory dynamics, the breathing rate was used because it has been shown to be the most reliable and sensitive parameter5.
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DRISCOLL, P., DEUBER, A., BAETTIG, K. et al. Effect of Filtered Cigarette Smoke on Rats. Nature 237, 37–38 (1972). https://doi.org/10.1038/237037a0
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DOI: https://doi.org/10.1038/237037a0
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