Letter | Published:

Possible Biochemical Model for Phenylketonuria


SINCE the demonstration of the primary enzymatic defect in phenylketonuria (PKU) several models have been suggested for this metabolic disorder. No hypothesis, however, has unified the biochemical and clinical characteristics2.

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    Jervis, G. A., Proc. Soc. Exp. Biol., 82, 514 (1953).

  2. 2

    Menkes, J. H., Pediatrics, 39, 297 (1967).

  3. 3

    Weber, G., Glazer, R. L., and Ross, R. A., Adv. Enzyme Regulation, 8, 13 (1970).

  4. 4

    Bowden, J. A., McArthur III, C. L., and Fried, M., Biochem. Med., 5, 101 (1971).

  5. 5

    Dixon, M., Biochem. J., 55, 170 (1953).

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